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Merck
CN

B016

Benoxathian hydrochloride

solid

Synonym(s):

2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]-amino]-methyl]-1,4-benzoxathian hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H23NO4S · HCl
CAS Number:
92642-97-2
Molecular Weight:
397.92
NACRES:
NA.77
PubChem Substance ID:
24277758
UNSPSC Code:
12352202
MDL number:
MFCD00055188

Key Documents

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Product Name

Benoxathian hydrochloride, solid

InChI

1S/C19H23NO4S.ClH/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14;/h3-9,14,20H,10-13H2,1-2H3;1H

SMILES string

Cl.COc1cccc(OC)c1OCCNCC2CSc3ccccc3O2

InChI key

OWRADFDDJVNMGL-UHFFFAOYSA-N

form

solid

color

white

solubility

H2O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.)
ethanol: soluble
isopropanol: soluble

Quality Level

100

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Biochem/physiol Actions

Selective α1-adrenoceptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
117H46572
117H4657

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S Ma et al.
Journal of neuroendocrinology, 17(1), 22-28 (2005-02-22)
Activation of the brain noradrenergic system during stress plays an important integrative function in coping and stress adaptation by facilitating transmission in many brain regions involved in regulating behavioural and physiological components of the stress response. The medial amygdala (MeA)
Jessica A Cardin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(35), 7745-7753 (2004-09-03)
Norepinephrine (NE) plays a complex role in the behavioral state-dependent regulation of sensory processing. However, the role of forebrain NE action in modulating high-order sensory activity has not been directly addressed. In this study, we take advantage of the discrete
Derek Lupinsky et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(22), 7624-7633 (2010-06-04)
While stressors are known to increase medial prefrontal cortex (PFC) glutamate (GLU) levels, the mechanism(s) subserving this response remain to be elucidated. We used microdialysis and local drug applications to investigate, in male Long-Evans rats, whether the PFC GLU stress
C H Brown et al.
The Journal of physiology, 507 ( Pt 3), 831-842 (1998-05-23)
1. We have tested the hypothesis that morphine withdrawal excitation of oxytocin neurones that follows from administration of naloxone to morphine-dependent rats is a consequence of excitation of noradrenergic neurones. 2. Female rats were made morphine dependent by intracerebroventricular (i.c.v.)
S Ma et al.
Journal of neuroendocrinology, 17(11), 761-769 (2005-10-13)
Chronic intermittent cold stress sensitises activation of the hypothalamic-pituitary-adrenal (HPA) axis by novel acute stress. We have shown that enhanced noradrenergic function in limbic forebrain contributes to HPA sensitisation. In the present study, we investigated whether chronic intermittent cold also
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