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Safety Information

AV50225

Sigma-Aldrich

Anti-SLAMF6 (AB2) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-KALI, Anti-KALIb, Anti-Ly108, Anti-MGC104953, Anti-NTB-A, Anti-NTBA, Anti-SF2000, Anti-SLAM family member 6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

34 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_443163

UniProt accession no.

B2R8X8

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... SLAMF6(114836)

Immunogen

Synthetic peptide directed towards the N terminal region of human SLAMF6

Application

Anti-SLAMF6 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.

Biochem/physiol Actions

SLAM family member 6 (SLAMF6) is a type I transmembrane protein that is involved in natural killer (NK) cell activation in association with SH2 domain-containing phosphatases (SHPs). It is expressed on NK, T and B cells.

Sequence

Synthetic peptide located within the following region: EIHVTNPKQGKRLNFTQSYSLQLSNLKMEDTGSYRAQISTKTSAKLSSYT

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC19949

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Laurence Menard et al.
The Journal of allergy and clinical immunology, 133(4), 1149-1161 (2014-01-01)
Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) can mediate the function of SLAM molecules, which have been proposed to be involved in the development of autoimmunity in mice. We sought to determine whether the SLAM/SAP pathway regulates the establishment of
Timothy J Wilson et al.
PloS one, 9(3), e92184-e92184 (2014-03-20)
SLAM family receptors regulate activation and inhibition in immunity through recruitment of activating and inhibitory SH2 domain containing proteins to immunoreceptor tyrosine based switch motifs (ITSMs). Binding of the adaptors, SAP and EAT-2 to ITSMs in the cytoplasmic regions of

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