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AV47141

Sigma-Aldrich

Anti-ZDHHC17 (AB1) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-HIP14, Anti-HIP3, Anti-HSPC294, Anti-HYPH, Anti-KIAA0946, Anti-Zinc finger, DHHC-type containing 17

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

73 kDa

species reactivity

rat, human, mouse, bovine, guinea pig, horse, rabbit, dog

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_056151

UniProt accession no.

Q8IUH5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ZDHHC17(23390)

Immunogen

Synthetic peptide directed towards the middle region of human ZDHHC17

Application

Anti-ZDHHC17 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

Biochem/physiol Actions

ZDHHC17 is a palmitoyl acyl transferase (PAT) expressed primarily in insulin-positive cells in islets of Langerhans. Overexpression of HIP14 is related to a reduction in IL-1beta-induced NF-kappaB activity and it can also protect against IL-1beta-mediated apoptosis. Additionally, it is a ClipR-59 palmitoyltransferase that modifies the ClipR-59 plasma membrane binding and hence regulates the Akt signaling as well as Glut4 membrane translocation in adipocytes. It also facilitates the Mg2+ transport.

Sequence

Synthetic peptide located within the following region: LFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKP

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lukas Adrian Berchtold et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(37), E681-E688 (2011-06-28)
Type 1 diabetes (T1D) is a complex disease characterized by the loss of insulin-secreting β-cells. Although the disease has a strong genetic component, and several loci are known to increase T1D susceptibility risk, only few causal genes have currently been
Angela Goytain et al.
The Journal of biological chemistry, 283(48), 33365-33374 (2008-09-17)
Polyglutamine expansions of huntingtin protein are responsible for the Huntington neurological disorder. HIP14 protein has been shown to interact with huntingtin. HIP14 and a HIP14-like protein, HIP14L, with a 69% similarity reside in the Golgi and possess palmitoyl acyltransferase activity
Wenying Ren et al.
Molecular and cellular biology, 33(21), 4255-4265 (2013-09-05)
ClipR-59 interacts with Akt and regulates Akt compartmentalization and Glut4 membrane trafficking in a plasma membrane association-dependent manner. The association of ClipR-59 with plasma membrane is mediated by ClipR-59 palmitoylation at Cys534 and Cys535. To understand the regulation of ClipR-59
Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus.
Abazari, et al.
Journal of Cell Science, 136 (2023)

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