AV46349
Anti-ANP32E antibody produced in rabbit
affinity isolated antibody
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All Photos(3)
Synonym(s):
Anti-Acidic (leucine-rich) Nuclear phosphoprotein 32 family, member E, Anti-LANP-L, Anti-LANPL, Anti-MGC5350
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
31 kDa
species reactivity
bovine, horse, rabbit, human, dog, rat
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ANP32E(81611)
Immunogen
Synthetic peptide directed towards the middle region of human ANP32E
Application
Anti-ANP32E antibody produced in rabbit is suitable for western blotting at a concentration of 0.25μg/ml. It is also useful for immunohistochemistry at a concentration of 4-8μg/ml.
Biochem/physiol Actions
ANP32E [Acidic (leucine-rich) Nuclear phosphoprotein 32 family, member E] also referred to as LANP-L, LANPL or MGC5350 is a histone chaperone located on chromosome 1q22 and is primarily expressed in human peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. It facilitates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome. It also blocks the activity of protein phosphatase 2A (PP2A) but not the protein phosphatase 1. Additionally, it may play a pivotal role in cerebellar development and synaptogenesis.
Sequence
Synthetic peptide located within the following region: EDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDE
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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M Jiang et al.
Cytogenetic and genome research, 97(1-2), 68-71 (2002-11-20)
Leucine-rich acidic nuclear protein (LANP) is a member of the leucine-rich repeats (LRRs) superfamily. Here we report on a human homologue of LANP, encoded by the gene ANP32E (alias LANPL). The gene was cloned and identified during large-scale sequencing analysis
Arnaud Obri et al.
Nature, 505(7485), 648-653 (2014-01-28)
H2A.Z is an essential histone variant implicated in the regulation of key nuclear events. However, the metazoan chaperones responsible for H2A.Z deposition and its removal from chromatin remain unknown. Here we report the identification and characterization of the human protein
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