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AV45599

Sigma-Aldrich

Anti-NR3C2 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-MCR, Anti-MGC133092, Anti-MLR, Anti-MR, Anti-Nuclear receptor subfamily 3, group C, member 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

107 kDa

species reactivity

human, rabbit

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_000892

UniProt accession no.

P08235

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NR3C2(4306)

General description

Mineralocorticoid receptor/nuclear receptor subfamily 3, group C, member 2/ (NR3C2, MLR, MCR) is a nuclear receptor for mineralocorticoids (eg. aldosterone) and glucocorticoids (eg. cortisol) that activates expression of proteins involved with ionic (salt balance) and water transport such as the epithelial sodium channel, Na+/K+ pump and serum and glucocorticoid induced kinase (SGK1).

Specificity

Anti-NR3C2 polyclonal antibody reacts with chicken, human, mouse, and rat mineralocorticoid/ aldosterone receptors.

Immunogen

Synthetic peptide directed towards the middle region of human NR3C2

Application

Anti-NR3C2 polyclonal antibody is used to tag mineralocorticoid receptor protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of mineralocorticoid receptor in the mineralocorticoid and glucocorticoid ligand-dependent control of salt balance and water retention.

Biochem/physiol Actions

NR3C2 is a receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. It binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

Sequence

Synthetic peptide located within the following region: RRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPP

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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