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AV35634

Sigma-Aldrich

Anti-PITX2 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Paired-like homeodomain transcription factor 2

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

36 kDa

species reactivity

canine, rabbit, bovine, mouse, human, rat

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_000316

UniProt accession no.

Q99697

storage temp.

−20°C

Gene Information

human ... PITX2(5308)

General description

Paired-like homeodomain transcription factor 2 (PITX2) also known as pituitary homeobox 2 is a homeodomain transcription factor that regulates expression of genes critical for proper eye, tooth and abdominal organ development as well as expression of pituitary-specific genes including prolactin. Mutations in PITX2 cause Axenfeld-Rieger syndrome.

Immunogen

The immunogen for anti-PITX2 antibody: synthetic peptide derected towards the N terminal of human PITX2

Sequence

Synthetic peptide located within the following region: SAVSSSSCHHPQPLAMASVLAPGQPRSLDSSKHRLEVHTISDTSSPEAAE

Physical form

Lyophilized from PBS buffer with 2% sucrose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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J Drouin et al.
Molecular and cellular endocrinology, 140(1-2), 31-36 (1998-08-29)
A subfamily of bicoid-related homeodomain factors was recently discovered through its involvement in transcription of pituitary-specific genes. We isolated the first member of this family, Ptxl (pituitary homeobox 1), through its DNA binding properties whereas a second related gene, Ptx2
Jing Luo et al.
Cancer cell international, 19, 96-96 (2019-05-03)
The homeodomain transcription factor, PITX2 is associated with tumorigenesis of multiple cancers. In this research, we aimed to study the expression, function and mechanism of PITX2 in lung adenocarcinoma (LUAD). The TCGA dataset was used to analyze the expression and

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