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Safety Information

AV35046

Sigma-Aldrich

Anti-CLIC2 (AB1) antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Chloride intracellular channel 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

27 kDa

species reactivity

horse, rabbit, dog, rat, guinea pig, human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_001280

UniProt accession no.

O15247

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CLIC2(1193)

General description

CLIC2 codes for an intracellular chloride ion channel protein. CLIC2 forms pH-dependent chloride channels in in vitro conditions. Its chloride channel functions are modulated by pH levels and redox status. It interacts with skeletal ryanodine receptor (RyR1).
Rabbit Anti-CLIC2 antibody recognizes chicken, mouse, rat, rabbit, human, bovine, and canine CLIC2.

Immunogen

Synthetic peptide directed towards the C terminal region of human CLIC2

Application

Rabbit Anti-CLIC2 antibody is suitable for western blot applications at a concentration of 1.25 μg/ml.

Biochem/physiol Actions

Chloride intracellular channel 2 is a member of the p64 family, a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. CLIon Channel 2 encodes a protein that is detected in fetal liver and adult skeletal muscle tissue. CLIon Channel2 maps to the candidate region on chromosome X for incontinentia pigmenti.

Sequence

Synthetic peptide located within the following region: SAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSG

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC4437

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Xing Meng et al.
Journal of molecular biology, 387(2), 320-334 (2009-04-10)
Chloride intracellular channel 2 (CLIC2), a newly discovered small protein distantly related to the glutathione transferase (GST) structural family, is highly expressed in cardiac and skeletal muscle, although its physiological function in these tissues has not been established. In the
Brett A Cromer et al.
Journal of molecular biology, 374(3), 719-731 (2007-10-20)
Chloride intracellular channel (CLIC) proteins possess the remarkable property of being able to convert from a water-soluble state to a membrane channel state. We determined the three-dimensional structure of human CLIC2 in its water-soluble form by X-ray crystallography at 1.8-A

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