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AV33314

Sigma-Aldrich

Anti-SNAI1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Snail homolog 1 (Drosophila)

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

29 kDa

species reactivity

human, rat, guinea pig, mouse

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_005976

UniProt accession no.

O95863

application(s)

research pathology

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SNAI1(6615)

General description

Snail homolog 1 (Drosophila) (SNAI1), a zinc finger transcription factor, is a transcription repressor that down-regulates the expression of ectodermal genes within the mesoderm. SNAI1 triggers the initiation of epithelial to mesenchymal transition (EMT), a process that provies epithelial cells with mesenchymal features and invasive properties during embryonic development and tumor progression. Consequently, Snai1 plays a major role in tumor growth, cell invasion and metastasis.

Specificity

Rabbit polyclonal anti-SNAI1 antibody reacts with human, mouse, and rat Snail homolog 1 proteins.

Immunogen

Synthetic peptide directed towards the N terminal of human SNAI1.

Application

Rabbit polyclonal anti-SNAI1 antibody is used to tag Snail homolog 1 (Drosophila)for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of Snail homolog 1 in epithelial to mesenchymal transition (EMT) during embryogenesis and tumor progression.

Sequence

Synthetic peptide located within the following region: MPRSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEIL

Physical form

Lyophilized from PBS buffer with 2% sucrose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC2834

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Weidong Zhao et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 36(4), E223-E233 (2013-08-03)
Epithelial-mesenchymal transition (EMT) is crucial for tumor progression and metastasis. Snail family members, including Snail, Slug and Smuc, are the transcription factors that repress E-cadherin expression and induce epithelial-mesenchymal transition in some tumor tissues. In this study, the expression of
Seung-Hyun Jeong et al.
Molecular medicine reports, 14(6), 5148-5154 (2016-10-26)
Hypoxia-induced epithelial-mesenchymal transition (EMT) has been identified as essential for tumor progression and metastasis. The present study examined the effects of an antioxidant, dieckol, on hypoxia‑induced EMT in HT29 human colorectal cancer cells. HT29 cells were treated with a hypoxia‑inducing
Damian Ryszawy et al.
Carcinogenesis, 35(9), 1920-1930 (2014-02-08)
Suppressive function of connexin(Cx)43 in carcinogenesis was recently contested by reports that showed a multifaceted function of Cx43 in cancer progression. These studies did not attempt to model the dynamics of intratumoral heterogeneity involved in the metastatic cascade. An unorthodox

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