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Safety Information

AV30228

Sigma-Aldrich

Anti-TERF2 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-TRBF2, Anti-TRF2, Anti-Telomeric repeat binding factor 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

55 kDa

species reactivity

mouse, human, bovine, dog, rabbit, guinea pig, horse, rat

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_005643

UniProt accession no.

Q15554

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TERF2(7014)

General description

TERF2 is a telomeric protein that forms a part of the telomere nucleoprotein complex. TERF2 is known to regulate the length of telomeres and is also known to protect telomeres.
Rabbit Anti-TERF2 antibody recognizes human, mouse, rat, bovine, and canine TERF2.

Immunogen

Synthetic peptide directed towards the C terminal region of human TERF2

Application

Rabbit Anti-TERF2 antibody is suitable for use in western blot at a concentration of 5.0μg/ml.

Biochem/physiol Actions

TERF2 is a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Sequence

Synthetic peptide located within the following region: TVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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