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Merck
CN

A9554

Allatostatin IV

≥97% (HPLC)

Synonym(s):

Asp-Arg-Leu-Tyr-Ser-Phe-Gly-Leu-NH2

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About This Item

Empirical Formula (Hill Notation):
C45H68N12O12
CAS Number:
123338-13-6
Molecular Weight:
969.09
UNSPSC Code:
12352202
PubChem Substance ID:
329771053
NACRES:
NA.26
MDL number:
MFCD00080034

Key Documents

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Product Name

Allatostatin IV, ≥97% (HPLC)

SMILES string

CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(N)=O

InChI key

BYSKWCFHMJZUBY-POFDKVPJSA-N

InChI

1S/C45H68N12O12/c1-24(2)17-31(38(47)63)52-36(60)22-51-40(65)33(19-26-9-6-5-7-10-26)55-44(69)35(23-58)57-43(68)34(20-27-12-14-28(59)15-13-27)56-42(67)32(18-25(3)4)54-41(66)30(11-8-16-50-45(48)49)53-39(64)29(46)21-37(61)62/h5-7,9-10,12-15,24-25,29-35,58-59H,8,11,16-23,46H2,1-4H3,(H2,47,63)(H,51,65)(H,52,60)(H,53,64)(H,54,66)(H,55,69)(H,56,67)(H,57,68)(H,61,62)(H4,48,49,50)/t29-,30-,31-,32-,33-,34-,35-/m0/s1

assay

≥97% (HPLC)

form

powder

color

white

storage temp.

−20°C

Biochem/physiol Actions

Allatostatin IV, an octapeptide amine, is a member of the allatoregulatory peptide family found in insects which either inhibit (allatostatins) or stimulate (allatotropins) juvenile hormone (JH) synthesis.
Inhibitor of juvenile hormone synthesis in insects.

Other Notes

Sequence highly conserved within the six C-terminal amino acids.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBT2448
SLBH6332V
SLBB7532V
041M1403V
041M1403

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Sabine Kreissl et al.
The Journal of comparative neurology, 518(9), 1391-1417 (2010-02-27)
Information transmission and processing in the brain is achieved through a small family of chemical neurotransmitters and neuromodulators and a very large family of neuropeptides. In order to understand neural networks in the brain it will be necessary, therefore, to
Zhentao Sheng et al.
Insect biochemistry and molecular biology, 37(1), 90-96 (2006-12-19)
In a previous study, allatotropic and allatostatic activities were observed in brain extract from the Eri silkworm, Samia cynthia ricini (Samcri) [Li, S., Jiang, R.-J., Cao, M.-X., 2002b. Allatotropic and allatostatic activities in brain extracts of the Eri silkworm, S.
N Audsley et al.
Journal of insect physiology, 54(6), 969-980 (2008-04-02)
Allatoregulatory peptides either inhibit (allatostatins) or stimulate (allatotropins) juvenile hormone (JH) synthesis by the corpora allata (CA) of insects. However, these peptides are pleitropic, the regulation of JH biosynthesis is not their only function. There are currently three allatostatin families
Liang Liang et al.
Cell, 181(7), 1680-1692 (2020-06-27)
Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy, we analyzed the untargeted metabolome of

Protocols

Protocol for In-vitro Permeation Testing Using Strat-M® Membranes

Strat-M® synthetic membrane mimics the human skin for In-vitro permeation testing (IVPT) of topical and transdermal formulations

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