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Safety Information

A9210

Sigma-Aldrich

Annexin V FITC Conjugate from human placenta

Synonym(s):

Annexin V, Calphosbindin I, Lipocortin V, PAP-1

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100 ML
CN¥444.94

CN¥444.94

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100 ML
CN¥444.94

About This Item

UNSPSC Code:
41106305
NACRES:
NA.32

CN¥444.94

Please contact Customer Service for Availability
Request a Bulk Order

form

buffered aqueous solution

Quality Level

300

extent of labeling

1-2 mol FITC per mol annexin V

UniProt accession no.

P08758

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... ANXA5(308)

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1 of 4

This Item
A8456SBR0001516967
Pefabloc® SC certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

15633

Pefabloc® SC

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride ≥97.0% (HPLC)

A8456

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

AEBSF Ready Made Solution

SBR00015

AEBSF Ready Made Solution

Trimethoprim certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

16967

Trimethoprim

technique(s)

gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

format

-

format

-

format

neat

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

300

grade

certified reference material, TraceCERT®

grade

-

grade

-

grade

certified reference material, TraceCERT®

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Application

For detection of apoptotic cells by flow cytometry or fluorescence microscopy.

Biochem/physiol Actions

Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium.
Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium. The cellular changes involved in the apoptotic process include loss of phospholipid asymmetry during the early stages. This phenomenon is universal and is not limited to stimulus or to mammalian cells, but also occurs in insect and plant cells. In living cells, phosphatidylserine is transported to the inside of the lipid bilayer by the Mg2+ATP dependent enzyme, aminophospholipid translocase. At the onset of apoptosis, phosphatidylserine becomes translocated to the external surface of the cell membrane. Since the movement of phosphatidylserine from the internal membrane surface to the external surface is an early indicator of apoptosis, annexin V and its conjugates that interact strongly and specifically with phosphatidylserine may be used to detect apoptosis. Annexin V conjugates can be used to detect apoptotic cells significantly earlier than DNA-based assays. Fluorescent dye labeled annexin V have applications in flow cytometry, fluorescence microscopy, and laser scanning cytometry.

Packaging

Package size based on protein content

Physical form

Solution in 50 mM Tris-HCl, pH 7.5, containing 100 mM NaCl.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000128509
    0000087654
    029M4120V
    11181155
    096M4085V

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