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A9187

Sigma-Aldrich

Adenosine 5′-triphosphate magnesium salt

≥95%, bacterial

Synonym(s):

ATP, ATP magnesium salt

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About This Item

Empirical Formula (Hill Notation):
C10H16N5O13P3 · xMg2+
CAS Number:
74804-12-9
Molecular Weight:
507.18 (free acid basis)
MDL number:
MFCD00084767
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24891422
NACRES:
NA.51

biological source

bacterial

Quality Level

200

Assay

≥95%

form

powder

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

[Mg].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H16N5O13P3.Mg.2H/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;

InChI key

CPGAIACWYFBIFN-UHFFFAOYSA-N

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Application

Adenosine 5′-triphosphate magnesium salt has been used:
  • as a supplement in intracellular medium for Ca2+ retention assay and fluorescence wide field imaging analysis
  • as a component in potassium methane sulfonate-based internal solution for in vitro electrophysiology of cortical neurons
  • as a component in action potential intracellular solution

Biochem/physiol Actions

Adenosine 5γ-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H371

Hazard Classifications

STOT SE 2

Target Organs

Eyes,Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000410064
0000408936
0000408933
0000410064
0000408933

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Hyun Jong Kim et al.
European journal of pharmacology, 791, 686-695 (2016-10-30)
Pyrazole derivatives were originally suggested as selective blockers of the transient receptor potential cation 3 (TRPC3) and channel. In particular, pyr3 and 10 selectively inhibit TRPC3, whereas pyr2 (BTP2) and 6 inhibit ORAI1. However, their effects on background K+ channel
Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.
Fenske S, et al.
Nature Protocols, 11(1), 61-61 (2016)
Lea Wagmann et al.
Archives of toxicology, 92(9), 2875-2884 (2018-08-08)
Transporter-mediated drug-drug interactions (DDI) may induce adverse clinical events. As drugs of abuse (DOA) are marketed without preclinical safety studies, only very limited information about interplay with membrane transporters are available. Therefore, 13 DOA of various classes were tested for
Spatial separation of mitochondrial calcium uptake and extrusion for energy-efficient mitochondrial calcium signaling in the heart.
De La Fuente S, et al.
Cell reports, 24(12), 3099-3107 (2018)
A subpopulation of striatal neurons mediates Levodopa-induced dyskinesia.
Girasole AE, et al.
Neuron, 97(4), 787-795 (2018)
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