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form
lyophilized powder
Quality Level
specific activity
1000-3000 units/mg protein
composition
Protein, ≤10%
packaging
vial of ≥80 μg protein
storage temp.
−20°C
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Application
ADP-ribosylcyclase is a Ca2+ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance .
Biochem/physiol Actions
ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .
Unit Definition
One unit will produce 1 μmole of cyclic ADP ribose from β-NAD+ in 5 minutes at pH 7.0 and 25°C.
Physical form
Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
动植物源性产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Heather S Loring et al.
Biochemistry, 59(8), 933-942 (2020-02-13)
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases. Importantly, SARM1 knockdown or knockout prevents degeneration, thereby demonstrating that SARM1
Lynn C Hull et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 1042-1050 (2010-06-17)
Our previous studies have demonstrated that an increase in intracellular levels of Ca(2+) in neurons is an important component of both the antinociception produced by morphine and morphine's tolerance. The present study tested the hypothesis that the Ca(2+) signaling second
Xiaojian Shao et al.
Nature protocols, 15(9), 2813-2836 (2020-08-05)
Several noncanonical initial nucleotides (NCINs) have been found to cap RNAs and possibly regulate RNA stability, transcription and translation. NAD+ is one of the NCINs that has recently been discovered to cap RNAs in a wide range of species. Identification
H C Lee et al.
Cell regulation, 2(3), 203-209 (1991-03-01)
Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate (IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme responsible for synthesizing cADPR is found not only in sea urchin
Nicholas D Peterson et al.
eLife, 11 (2022-02-01)
Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress - a process known as phase transition. Here, we show that a phase transition of the Caenorhabditis elegans Toll/interleukin-1 receptor domain protein
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