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A9062

Sigma-Aldrich

Adenosine 5′-triphosphate di(tris) salt hydrate

≥95%

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Synonym(s):
ATP, 5′-ATP-DiTris
Empirical Formula (Hill Notation):
C10H16N5O13P3 · 2C4H11NO3 · xH2O
CAS Number:
102047-34-7
Molecular Weight:
749.45 (anhydrous basis)
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24891222
NACRES:
NA.51

biological source

(Fermentation)

Quality Level

200

Assay

≥95%

form

powder

solubility

H2O: 50 mg/mL

cation traces

Na: ≤0.1%

shipped in

dry ice

storage temp.

−20°C

SMILES string

O.NC(CO)(CO)CO.NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2C4H11NO3.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;2*5-4(1-6,2-7)3-8;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);2*6-8H,1-3,5H2;1H2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

ZMNHJZFDZFGOFE-MSQVLRTGSA-N

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Application

Adenosine 5′-triphosphate di(tris) salt hydrate has been used:
  • to treat cells for Ca2+ influx measurements in stromal interaction molecule 1 knockout (STIM1−/−) mice and in vitro chemotaxis assay for microglial migration
  • supplemented in buffer C for mitochondrial respiratory control assay and complex V activity assay
  • in the inhibition of silver nano particles (AgNPs) on Na+/K+-ATPase activity

Biochem/physiol Actions

Adenosine 5′-triphosphate di(tris) salt dehydrate is useful in applications that require the absence of metals.
Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Caution

Unstable: For maximum stability, store as frozen solution at pH 3.5 to 6.8.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart.
McLaughlin KL, et al.
Biochemical and biophysical research communications, 504(4), 742-748 (2018)
Silver nanoparticle-protein interactions in intact rainbow trout gill cells.
Yue Y, et al.
Environmental science. Nano, 3(5), 1174-1185 (2016)
C Valentin-Ranc et al.
The Journal of biological chemistry, 266(12), 7668-7675 (1991-04-25)
The fluorescence of N-acetyl-N'-(sulfo-1-naphthyl)ethylenediamine (AEDANS) covalently bound to Cys-374 of actin is used as a probe for different conformational states of G-actin according to whether Ca-ATP, Mg-ATP, or unchelated ATP is bound to the nucleotide site. Upon addition of large
Kelsey L McLaughlin et al.
Biochemical and biophysical research communications, 504(4), 742-748 (2018-09-16)
The progeroid phenotype of mitochondrial DNA (mtDNA) mutator mice has been nebulously attributed to general mitochondrial 'dysfunction', though few studies have rigorously defined the bioenergetic consequences of accumulating mtDNA mutations. Comprehensive mitochondrial diagnostics was employed to interrogate the bioenergetic properties
G Baffy et al.
British journal of cancer, 105(4), 469-474 (2011-06-30)
Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of adenosine 5'-triphosphate, which is also a key determinant of glycolytic pathways. In addition, UCP
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