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A9013

1,5-Bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide

Name: 1,5-Bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
Brand: SIGMA

≥97% (HPLC), acetylcholinesterase inhibitor, powder

Synonym(s):

BW 284c51

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About This Item

Linear Formula:

C₂₇H₃₈N₂OBr₂

CAS Number:

402-40-4

Molecular Weight:

566.41

UNSPSC Code:

12352200

PubChem Substance ID:

24278243

NACRES:

NA.77

MDL number:

MFCD00063485

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

200

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Properties

Product Name

1,5-Bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide,

assay

≥97% (HPLC)

Quality Level

200

form

powder

solubility

water: 19.60-20.40 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

Br.C[N](C)(CC=C)c1ccc(CCC(=O)CCc2ccc(cc2)[N](C)(C)CC=C)cc1

InChI

1S/C27H38N2O.BrH/c1-7-21-28(3,4)25-15-9-23(10-16-25)13-19-27(30)20-14-24-11-17-26(18-12-24)29(5,6)22-8-2;/h7-12,15-18H,1-2,13-14,19-22H2,3-6H3;1H

InChI key

XBXRQUYORADPMX-UHFFFAOYSA-N

Gene Information

human ... ACHE(43)

Description

Biochem/physiol Actions

Selective acetylcholinesterase inhibitor.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330

pcodes

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

0000496130

0000496132

0000492962

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The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane.

Silvia Olivera-Bravo et al.

British journal of pharmacology, 144(1), 88-97 (2005-01-13)

This work was aimed to determine if 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide (BW284c51), the most selective acetylcholinesterase inhibitor (AchEI), affects the nicotinic acetylcholine (Ach) receptor (AchR) function. Purified Torpedo nicotinic AchRs were injected into Xenopus laevis oocytes and BW284c51 effects on Ach- and

Baculovirus expression, biochemical characterization and organophosphate sensitivity of rBmAChE1, rBmAChE2, and rBmAChE3 of Rhipicephalus (Boophilus) microplus.

Kevin B Temeyer et al.

Veterinary parasitology, 172(1-2), 114-121 (2010-05-11)

Rhipicephalus (Boophilus) microplus cDNAs, BmAChE1, BmAChE2, and BmAChE3, were previously identified as presumptively encoding acetylcholinesterases (AChEs), but biochemical identity was confirmed only for recombinant BmAChE3. In the present study, four recombinant BmAChE1 constructs and single recombinant constructs of BmAChE2 and

Peripheral site acetylcholinesterase blockade induces RACK1-associated neuronal remodeling.

Noa Farchi et al.

Neuro-degenerative diseases, 4(2-3), 171-184 (2007-06-29)

Peripheral anionic site (PAS) blockade of acetylcholinesterase (AChE) notably affects neuronal activity and cyto-architecture, however, the mechanism(s) involved are incompletely understood. We wished to specify the PAS extracellular effects on specific AChE mRNA splice variants, delineate the consequent cellular remodeling

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Global Trade Item Number

SKU	GTIN
A9013-25MG	04061833401170
A9013-250MG	04061832945316
A9013-100MG	04061833401163