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Merck
CN

A8846

ProteoMass™ Angiotensin II MALDI-MS Standard

vial of 10 nmol

Synonym(s):

Angiotensin II, mass spec standard

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About This Item

NACRES:
NA.24
PubChem Substance ID:
329771018
UNSPSC Code:
41116107
MDL number:
MFCD00161484

Key Documents

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Product Name

ProteoMass™ Angiotensin II MALDI-MS Standard, vial of 10 nmol

InChI key

CZGUSIXMZVURDU-JZXHSEFVSA-N

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1

mol wt

monoisotopic mol wt 1,045.5423 Da

packaging

vial of 10 nmol

Quality Level

100

Gene Information

human ... AGTR1(185)

Related Categories

Application

ProteoMass™ Angiotensin II MALDI-MS Standard has been used:
  • as peptide calibration standard for MALDI-MS instruments
  • as a reference standard in Liquid chromatography–mass spectrometry (LC-MS/MS) analysis for characterizing RNase and NC1 domain of collagen IV
  • as a standard in testing infrared (IR) laser desorption/ionization (IR-LDI) method

Biochem/physiol Actions

Angiotensin II (Ang II) maintains cardiac functionality by coordinating with the angiotensin II receptors. Ang II is recommended for patients with vasodilatory shock.

General description

Angiotensin II (Ang II) is part of the renin-angiotensin cascade. It is an octapeptide. Ang II is present in high concentration in cardiac tissue.

Legal Information

ProteoMass is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000342569
0000342570
0000342569
0000342570
SLCQ0701

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Angiotensin II for the treatment of vasodilatory shock
Khanna A, et al.
The New England Journal of Medicine, 377(5), 419-430 (2017)
Ryuji Hiraguchi et al.
International journal of molecular sciences, 15(6), 10821-10834 (2014-06-18)
A continuous flow atmospheric pressure laser desorption/ionization technique using a porous stainless steel probe and a 6-7-µm-band mid-infrared tunable laser was developed. This ion source is capable of direct ionization from a continuous flow with a high temporal stability. The
Pyridoxamine protects proteins from damage by hypohalous acids in vitro and in vivo
Madu H, et al.
Free Radical Biology & Medicine, 89(5), 83-90 (2015)
Effect of solvent on ionization efficiency in matrix-assisted laser desorption/ionization mass spectrometry of peptides
Hazama H, et al.
Chemical Physics, 419(5), 196-199 (2013)
Molecular weight of different angiotensin II polymers directly determines: Density of endothelial membrane AT1 receptors and coronary vasoconstriction
Torres-Tirado D, et al.
Vascular Pharmacology, 58(5-6), 346-355 (2013)
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