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A8751

Sigma-Aldrich

Adenine hydrochloride hydrate

≥99%

Synonym(s):

Adenine hydrochloride, Adenine,monohydrochloride, 6-Aminopurine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C5H5N5 · HCl · xH2O
CAS Number:
2922-28-3
Molecular Weight:
171.59 (anhydrous basis)
MDL number:
MFCD00150864
UNSPSC Code:
41106305
PubChem Substance ID:
24891361
NACRES:
NA.51

Quality Level

200

Assay

≥99%

form

powder

SMILES string

O.Cl.Nc1ncnc2[nH]cnc12

InChI

1S/C5H5N5.ClH.H2O/c6-4-3-5(9-1-7-3)10-2-8-4;;/h1-2H,(H3,6,7,8,9,10);1H;1H2

InChI key

MYRDTAUFFBYTHA-UHFFFAOYSA-N

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General description

Adenine is a purine nucleobase with a wide range of chemical and biochemical roles in vivo and in vitro. It is a regulatory molecule and a component of DNA, RNA, cofactors (NAD, FAD), and signaling molecules (cAMP).

Application

Adenine hydrochloride hydrate has been used:

  • as a supplement in a rich medium for galactose induction during yeast cell culture.
  • for the incubation of MiaPaCa2 cell lines for cell viability and co-culture assay.
  • as a component of the Pombe Glutamate (PMG)media for the germination of Schizosaccharomyces pombe.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000369516
0000350142
0000336121
0000309482
0000309483

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Methylthioadenosine (MTA) Rescues Methylthioadenosine Phosphorylase (MTAP)-deficient tumors from purine synthesis inhibition in vivo via non-autonomous adenine supply
Astrid Ruefli-Brasse, et al.
Journal of Cancer Therapy, 2011 (2011)
Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo
Wiley DJ, et al.
Frontiers in Physiology, 11, 427-427 (2020)
Isabelle Loïodice et al.
Cells, 10(11) (2021-11-28)
In eukaryotic cells, silent chromatin is mainly found at the nuclear periphery forming subnuclear compartments that favor silencing establishment. Here, we set up an inducible system to monitor silencing establishment at an ectopic locus in relation with its subnuclear localization
David J Wiley et al.
Frontiers in physiology, 11, 427-427 (2020-05-22)
Arginyltransferase1 (ATE1) is a conserved enzyme in eukaryotes mediating posttranslational arginylation, the addition of an extra arginine to an existing protein. In mammals, the dysregulations of the ATE1 gene (ate1) is shown to be involved in cardiovascular abnormalities, cancer, and

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