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Merck
CN

A8751

Adenine hydrochloride hydrate

≥99%, powder

Synonym(s):

Adenine hydrochloride, Adenine,monohydrochloride, 6-Aminopurine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C5H5N5 · HCl · xH2O
CAS Number:
2922-28-3
Molecular Weight:
171.59 (anhydrous basis)
UNSPSC Code:
41106305
PubChem Substance ID:
24891361
NACRES:
NA.51
MDL number:
MFCD00150864

Key Documents

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Product Name

Adenine hydrochloride hydrate, ≥99%

SMILES string

O.Cl.Nc1ncnc2[nH]cnc12

InChI

1S/C5H5N5.ClH.H2O/c6-4-3-5(9-1-7-3)10-2-8-4;;/h1-2H,(H3,6,7,8,9,10);1H;1H2

InChI key

MYRDTAUFFBYTHA-UHFFFAOYSA-N

biological source

synthetic

assay

≥99%

form

powder

solubility

warm water: 50 mg/mL, clear to hazy, colorless to faint yellow or tan

Quality Level

200

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Application

Adenine hydrochloride hydrate has been used:

  • as a supplement in a rich medium for galactose induction during yeast cell culture.
  • for the incubation of MiaPaCa2 cell lines for cell viability and co-culture assay.
  • as a component of the Pombe Glutamate (PMG)media for the germination of Schizosaccharomyces pombe.

General description

Adenine is a purine nucleobase with a wide range of chemical and biochemical roles in vivo and in vitro. It is a regulatory molecule and a component of DNA, RNA, cofactors (NAD, FAD), and signaling molecules (cAMP).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000490266
0000490266
0000477042
0000477042
0000468373

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Methylthioadenosine (MTA) Rescues Methylthioadenosine Phosphorylase (MTAP)-deficient tumors from purine synthesis inhibition in vivo via non-autonomous adenine supply
Astrid Ruefli-Brasse, et al.
Journal of Cancer Therapy, 2011 (2011)
Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo
Wiley DJ, et al.
Frontiers in Physiology, 11, 427-427 (2020)
Isabelle Loïodice et al.
Cells, 10(11) (2021-11-28)
In eukaryotic cells, silent chromatin is mainly found at the nuclear periphery forming subnuclear compartments that favor silencing establishment. Here, we set up an inducible system to monitor silencing establishment at an ectopic locus in relation with its subnuclear localization
David J Wiley et al.
Frontiers in physiology, 11, 427-427 (2020-05-22)
Arginyltransferase1 (ATE1) is a conserved enzyme in eukaryotes mediating posttranslational arginylation, the addition of an extra arginine to an existing protein. In mammals, the dysregulations of the ATE1 gene (ate1) is shown to be involved in cardiovascular abnormalities, cancer, and

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