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A8626

Sigma-Aldrich

Adenine

≥99%

Synonym(s):

6-Aminopurine, Vitamin B4

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1 G
CN¥575.32
5 G
CN¥617.79
25 G
CN¥1,665.72
100 G
CN¥4,410.86
1 KG
CN¥20,403.71

CN¥575.32

Available to ship onApril 07, 2025Details

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1 G
CN¥575.32
5 G
CN¥617.79
25 G
CN¥1,665.72
100 G
CN¥4,410.86
1 KG
CN¥20,403.71

About This Item

Empirical Formula (Hill Notation):
C5H5N5
CAS Number:
73-24-5
Molecular Weight:
135.13
Beilstein:
5777
EC Number:
200-796-1
MDL number:
MFCD00041790
UNSPSC Code:
41106305
PubChem Substance ID:
24891349
NACRES:
NA.51

CN¥575.32

Available to ship onApril 07, 2025Details

biological source

synthetic

Assay

≥99%

form

powder

technique(s)

UV/Vis spectroscopy: suitable

color

white to off-white

mp

>360 °C (lit.)

solubility

0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan

storage temp.

room temp

SMILES string

Nc1ncnc2[nH]cnc12

InChI

1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)

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1 of 4

This Item
A5665PHR1383A2786
Adenine ≥99%

A8626

Adenine

Adenine BioReagent, suitable for plant cell culture, ≥99%

A5665

Adenine

Adenine Pharmaceutical Secondary Standard; Certified Reference Material

PHR1383

Adenine

Adenine BioReagent, suitable for cell culture

A2786

Adenine

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

200

assay

≥99%

assay

≥99%

assay

-

assay

≥99%

form

powder

form

powder

form

-

form

powder

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

storage temp.

room temp

solubility

0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan

solubility

0.5 M HCl: soluble 20 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

-

solubility

0.5 M HCl: soluble 20 mg/mL, clear to slightly hazy, colorless to faintly yellow

General description

Adenine is a purine nucleobase.[1] It is part of DNA,[1] and RNA.[2] Adenine is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP).

Application

Adenine is suitable for use:
  • as a component of boron-deficient media to grow yeast in order to assess whether yeast growth is stimulated by boron[3]
  • as a food supplement for adult rats to investigate the effects of dietary adenine overload[4]
  • as a nucleic acid base supplement in the basal media used to grow anaerobic Bacillus mojavensis and Bacillus subtilis in a study to show that DNA or deoxyribonucleosides are required for the anaerobic growth of these bacteria[5]
  • as an additive to investigate the effects of adenine on CH4 production and on fermentation by ruminal batch cultures from nonlactating Holstein cows[6]
  • as a part of adenine diet in rats in a study to identify blood markers for early stages of adenine-induced chronic kidney disease (CKD)[7]

Biochem/physiol Actions

Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP.[1] ATP is the energy currency of the cell and is required during cellular metabolism.[8] Adenine is metabolized to is 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats.[9] Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    WXBF5190V
    WXBF2591V
    WXBF3117V
    WXBF4385V
    WXBF1093V

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    Adenine: an important drug scaffold for the design of antiviral agents
    Wang C, et al.
    Acta Pharmaceutica Sinica. B, 5(5), 431-441 (2015)
    A novel approach to adenine-induced chronic kidney disease associated anemia in rodents
    Rahman A, et al.
    PLoS ONE, 13(2), e0192531-e0192531 (2018)
    Energy transfer from adenosine triphosphate
    Ross J
    The Journal of Physical Chemistry B, 110(13), 6987-6990 (2006)
    The prebiotic role of adenine: a critical analysis
    Shapiro R
    Origins of Life and Evolution of the Biosphere : the Journal of the International Society For the Study of the Origin of Life, 25(1-3), 83-98 (1995)
    Toshihiro Kobayashi et al.
    Analytical and bioanalytical chemistry, 406(5), 1365-1376 (2013-11-16)
    To identify blood markers for early stages of chronic kidney disease (CKD), blood samples were collected from rats with adenine-induced CKD over 28 days. Plasma samples were subjected to metabolomic profiling by liquid chromatography-mass spectrometry, followed by multivariate analyses. In
    View All Related Papers

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