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A8606

Sigma-Aldrich

Anti-α2C Adrenergic Receptor antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-α-2-adrenergic receptor, renal type, Anti-ADRA2C, Anti-ADRA2L2, Anti-ALPHA2CAR
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

immunohistochemistry: 1:100-1:300
western blot: 1:500-1:1,000

UniProt accession no.

P18825

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADRA2C(152)
mouse ... Adra2c(11553)
rat ... Adra2c(24175)

General description

Adrenergic receptors are a G-protein coupled receptors that exist in two forms, α or β. Ligands for adrenergic receptors are catecholamines that induce a sympathetic response in animal cells.
Studies have reported that α2C adrenergic receptors can regulate adrenergic opioid synergy and spinal analgesia. Rabbit Anti-α2C Adrenergic Receptor antibody binds to humanα2C Adrenergic Receptor.

Immunogen

synthetic peptide corresponding to an internal sequence of human α2C Adrenergic Receptor.

Application

Rabbit Anti-α2C Adrenergic Receptor antibody can be used for immunohistochemistry (1:100-1:300) and western blot (1:500-1:1,000) applications.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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Carolyn A Fairbanks et al.
The Journal of pharmacology and experimental therapeutics, 300(1), 282-290 (2001-12-26)
The alpha(2A)-adrenergic receptor (AR) subtype mediates antinociception induced by the alpha(2)AR agonists clonidine, dexmedetomidine, norepinephrine, and 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine (UK-14,304) as well as antinociceptive synergy of UK-14,304 with opioid agonists [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin and deltorphin II. Differential localization of alpha(2)-adrenergic (alpha(2A)-, alpha(2B)-(,) alpha(2C)-) and

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