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A8301

Sigma-Aldrich

Albumin, glycated human

lyophilized powder

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CAS Number:
70024-90-7
MDL number:
MFCD00130433
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

200

Assay

90-100% protein basis (biuret)

form

lyophilized powder

extent of labeling

1-5 mol hexose (as fructosamine) per mol albumin

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P02768

storage temp.

−20°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

Gene Information

human ... ALB(213)

Related Categories

General description

Albumin gene is mapped to human chromosome 4q13.3. It is synthesized as a preproalbumin with 609 amino acids in the liver. The mature albumin comprising 585 residues, is generated by the cleavage of signal peptide. Albumin is the major circulating protein in serum. It comprises three domains (I, II and III), each of which is subdivided into two subdomains A and B. A total of six ligand binding site is associated with albumin. Domain IIA and IIIA harbor small heterocyclic or aromatic compounds binding site. Long-chain fatty acid binding sites is present in IB and IIIB domains.

Application

Albumin, glycated human has been used:
  • as a component of serum-free medium for retinal microglia activation
  • to stimulate immortalised proximal tubule epithelial (HK-2) cells for fibronectin production
  • as medium supplement in human retinal microvascular endothelial cells (HRMECs) cultures to test its effect on family with sequence similarity 18, member B (FAM18B) expression


Naturally occurring glycated albumin is a sensitive indicator of glycemic control by diabetic patients.

Biochem/physiol Actions

Albumin is crucial for physiological processes and is the major transporter for lipids, metal ions and amino acids. It has antioxidant functionality and binds to drugs as well. Mutation in the albumin gene is implicated in an autosomal recessive disorder called Analbuminemia, which is characterized by low levels of albumin. The major glycation site is lysine 525 in albumin. Glycated albumin is a marker of glycemia in diabetes mellitus patients and is useful in assessment of HbA1c based glycemic control.

Physical form

Lyophilized powder containing citrate buffer salts

Preparation Note

Glycated in vitro

Other Notes

View more information on human serum albumin.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the carbohydrate used for the glycation step of Product A8301, Albumin, glycated human?

    The starting carbohydrate for the albumin modification is glucose.

  4. How much is Product A8301, Albumin, glycated human, glycated?

    The degree of glycation varies with each individual lot.  This value can be found on the Certificate of Analysis for each lot. 

  5. What is the molecular weight of Product A8301, Albumin, glycated human?

    Because the degree of glycation varies with each lot, the calculated molecular weight (MW) varies with each lot.  The parent albumin has a molecular weight of approximately 66,478 Daltons. Each hexose unit adds approximately 180 Daltons to the molecular weight.

  6. How do I find price and availability?

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  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Role of FAM18B in diabetic retinopathy
Wang AL, et al.
Molecular Vision, 20(1), 1146-1146 (2014)
A novel mutation in the albumin gene (c. 1A> C) resulting in analbuminemia
Caridi G, et al.
European Journal of Clinical Investigation, 43(1), 72-78 (2013)
Glycated albumin is a better glycemic indicator than glycated hemoglobin values in hemodialysis patients with diabetes: effect of anemia and erythropoietin injection
Inaba M, et al.
Journal of the American Society of Nephrology, 18(3), 896-903 (2007)
Mizuho Nakayama et al.
Nature communications, 11(1), 2333-2333 (2020-05-13)
Missense-type mutant p53 plays a tumor-promoting role through gain-of-function (GOF) mechanism. In addition, the loss of wild-type TP53 through loss of heterozygosity (LOH) is widely found in cancer cells. However, malignant progression induced by cooperation of TP53 GOF mutation and
AGEs mediated expression and secretion of TNF alpha in rat retinal microglia
Wang AL, et al.
Experimental Eye Research, 84(5), 905-913 (2007)
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