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A8301

Sigma-Aldrich

Albumin, glycated human

lyophilized powder

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About This Item

CAS Number:
70024-90-7
MDL number:
MFCD00130433
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

200

Assay

90-100% protein basis (biuret)

form

lyophilized powder

extent of labeling

1-5 mol hexose (as fructosamine) per mol albumin

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P02768

storage temp.

−20°C

SMILES string

FC(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

Gene Information

human ... ALB(213)

Related Categories

General description

Albumin gene is mapped to human chromosome 4q13.3. It is synthesized as a preproalbumin with 609 amino acids in the liver. The mature albumin comprising 585 residues, is generated by the cleavage of signal peptide. Albumin is the major circulating protein in serum. It comprises three domains (I, II and III), each of which is subdivided into two subdomains A and B. A total of six ligand binding site is associated with albumin. Domain IIA and IIIA harbor small heterocyclic or aromatic compounds binding site. Long-chain fatty acid binding sites is present in IB and IIIB domains.

Application

Albumin, glycated human has been used:
  • as a component of serum-free medium for retinal microglia activation
  • to stimulate immortalised proximal tubule epithelial (HK-2) cells for fibronectin production
  • as medium supplement in human retinal microvascular endothelial cells (HRMECs) cultures to test its effect on family with sequence similarity 18, member B (FAM18B) expression


Naturally occurring glycated albumin is a sensitive indicator of glycemic control by diabetic patients.

Biochem/physiol Actions

Albumin is crucial for physiological processes and is the major transporter for lipids, metal ions and amino acids. It has antioxidant functionality and binds to drugs as well. Mutation in the albumin gene is implicated in an autosomal recessive disorder called Analbuminemia, which is characterized by low levels of albumin. The major glycation site is lysine 525 in albumin. Glycated albumin is a marker of glycemia in diabetes mellitus patients and is useful in assessment of HbA1c based glycemic control.

Physical form

Lyophilized powder containing citrate buffer salts

Preparation Note

Glycated in vitro

Other Notes

View more information on human serum albumin.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000280784
0000280784
SLCL5490
SLCG2829
SLCD5260

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the carbohydrate used for the glycation step of Product A8301, Albumin, glycated human?

    The starting carbohydrate for the albumin modification is glucose.

  4. How much is Product A8301, Albumin, glycated human, glycated?

    The degree of glycation varies with each individual lot.  This value can be found on the Certificate of Analysis for each lot. 

  5. What is the molecular weight of Product A8301, Albumin, glycated human?

    Because the degree of glycation varies with each lot, the calculated molecular weight (MW) varies with each lot.  The parent albumin has a molecular weight of approximately 66,478 Daltons. Each hexose unit adds approximately 180 Daltons to the molecular weight.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

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    Ask a Scientist here.

Role of FAM18B in diabetic retinopathy
Wang AL, et al.
Molecular Vision, 20(1), 1146-1146 (2014)
Stephanie D Burr et al.
Cells, 10(3) (2021-04-04)
Cardiovascular disease, specifically heart failure, is a common complication for individuals with type 2 diabetes mellitus. Heart failure can arise with stiffening of the left ventricle, which can be caused by "active" cardiac fibroblasts (i.e., myofibroblasts) remodeling the extracellular matrix
AGEs mediated expression and secretion of TNF alpha in rat retinal microglia
Wang AL, et al.
Experimental Eye Research, 84(5), 905-913 (2007)
Mizuho Nakayama et al.
Nature communications, 11(1), 2333-2333 (2020-05-13)
Missense-type mutant p53 plays a tumor-promoting role through gain-of-function (GOF) mechanism. In addition, the loss of wild-type TP53 through loss of heterozygosity (LOH) is widely found in cancer cells. However, malignant progression induced by cooperation of TP53 GOF mutation and
Kevin P O'Rourke et al.
Nature biotechnology, 35(6), 577-582 (2017-05-02)
Colorectal cancer (CRC) is a leading cause of death in the developed world, yet facile preclinical models that mimic the natural stages of CRC progression are lacking. Through the orthotopic engraftment of colon organoids we describe a broadly usable immunocompetent
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