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A8208

Sigma-Aldrich

Atrial Natriuretic Peptide rat

≥97% (HPLC)

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Synonym(s):
α-Atriopeptin, rat, α-rANP, ANF (123-150), rat, ANF 1-28, rANP
Empirical Formula (Hill Notation):
C128H205N45O39S2
CAS Number:
88898-17-3
Molecular Weight:
3062.41
MDL number:
MFCD00076228
UNSPSC Code:
51111800
PubChem Substance ID:
329770951
NACRES:
NA.32

Quality Level

200

Assay

≥97% (HPLC)

form

powder

composition

Peptide content, ≥70%

UniProt accession no.

P01161

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4ccc(O)cc4)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)CC

InChI

1S/C128H205N45O39S2/c1-10-64(7)99-121(209)151-52-94(183)152-66(9)101(189)156-77(36-37-91(130)180)109(197)167-85(56-175)105(193)150-53-96(185)154-78(43-62(3)4)103(191)149-54-97(186)155-89(119(207)164-82(48-92(131)181)114(202)169-86(57-176)116(204)163-81(46-68-25-16-13-17-26-68)113(201)159-74(29-20-40-144-126(136)137)107(195)166-84(123(211)212)47-69-32-34-70(179)35-33-69)60-213-214-61-90(171-118(206)88(59-178)170-117(205)87(58-177)168-108(196)75(30-21-41-145-127(138)139)157-106(194)73(28-19-39-143-125(134)135)158-112(200)79(44-63(5)6)161-102(190)71(129)55-174)120(208)162-80(45-67-23-14-12-15-24-67)104(192)148-50-93(182)147-51-95(184)153-72(27-18-38-142-124(132)133)110(198)173-100(65(8)11-2)122(210)165-83(49-98(187)188)115(203)160-76(111(199)172-99)31-22-42-146-128(140)141/h12-17,23-26,32-35,62-66,71-90,99-100,174-179H,10-11,18-22,27-31,36-61,129H2,1-9H3,(H2,130,180)(H2,131,181)(H,147,182)(H,148,192)(H,149,191)(H,150,193)(H,151,209)(H,152,183)(H,153,184)(H,154,185)(H,155,186)(H,156,189)(H,157,194)(H,158,200)(H,159,201)(H,160,203)(H,161,190)(H,162,208)(H,163,204)(H,164,207)(H,165,210)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,173,198)(H,187,188)(H,211,212)(H4,132,133,142)(H4,134,135,143)(H4,136,137,144)(H4,138,139,145)(H4,140,141,146)/t64-,65-,66-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,99-,100-/m0/s1

InChI key

QGFSVPWZEPKNDV-BRTFOEFASA-N

Gene Information

rat ... Nppa(24602)

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Related Categories

Amino Acid Sequence

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide bridge: 7-23]

Application

Atrial Natriuretic Peptide rat has been used:
  • In the absorption test to confirm the specificity of the anti-NP antibodies.
  • To study the effects of atrial natriuretic peptide (ANP) on renal water and sodium regulation in rats.
  • To study the integrated biological effects of ANP on myocardial infarction using mice models.

Biochem/physiol Actions

ANP production is regulated by factors associated with developmental, hormonal and hemodynamic processes. Its secretion is stimulated by atrial wall stretch, and ischemia.
Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.

Other Notes

Lyophilized from 0.1% TFA in H2O

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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Natriuretic peptides are localized to rat retinal amacrine cells
Jin Y, et al.
Neuroscience Letters, 421(2), 106-109 (2007)
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Wang W, et al.
American Journal of Physiology: Renal Physiology, 290(2), F530-F541 (2006)
Atrial natriuretic peptide increases inflammation, infarct size, and mortality after experimental coronary occlusion
Houng AK, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 296(3), H655-H661 (2009)
Effects of endothelin family on ANP secretion
Yuan K, et al.
Peptides, 82, 12-19 (2016)
GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia
Lilyanna S, et al.
Journal of Molecular and Cellular Cardiology, 87, 27-37 (2015)
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