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A7223

Sigma-Aldrich

Albumin human

recombinant, expressed in Pichia pastoris, 5% in aqueous buffer, ≥90% (SDS-PAGE)

Synonym(s):

Albagen™, rHSA

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About This Item

Empirical Formula (Hill Notation):
C2936H4624N786O889S41
CAS Number:
70024-90-7
Molecular Weight:
66471.53
MDL number:
MFCD00081418
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

200

recombinant

expressed in Pichia pastoris

Assay

≥90% (SDS-PAGE)

form

solution

mol wt

monomer ~67 kDa

concentration

5% in aqueous buffer

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P02768

shipped in

wet ice

storage temp.

2-8°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

Gene Information

human ... ALB(213)

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Application

This recombinant variant is recommended for use in absorption, distribution, metabolism, and excretion (ADME) pharmacological research; cell culture; drug delivery research; and cryopreservation of cells.

Biochem/physiol Actions

Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.

Physical properties

Recombinant construct with N-terminal deletion of Asp. Structurally equivalent to native albumin by x-ray crystallography. The N-terminal Asp is the principal Cu2+ and Ni2+ chelation site; its deletion eliminates an important antigenic determinant, and the protein is hypoallergenic. Also blocked at Cys34 to improve stability, monomer content and homogeneity.

Physical form

Solution in phosphate buffered saline containing 4 mM sodium caprylate and 4 mM N-acetyltryptophan.

Other Notes

View more information on human serum albumin.

Legal Information

Albagen is a trademark of Albumin Therapeutics, LLC.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the concentration of Product A7223, Albumin human - recombinant?

    The concentration of this solution is 50 mg/mL.

  4. How many milliliters are in the 1 gram package size of Product A7223, Albumin human - recombinant?

    There are 20 mL of albumin solution in the 1 gram package size.

  5. What is the molecular mass of the recombinant albumin used in preparing Product A7223, Albumin human - recombinant?

    This recombinant protein contains 584 amino acid residues (66,357 Dalton) derived from the prototypical human serum albumin sequence, Gene Bank Accession No. M12523, with a single deletion of the N-terminal residue (Asp).  The N-terminal deletion of the Asp reduces the affinity by which nickel and copper bind to the protein.  Otherwise, the biological properties are identical as for the full-length protein.

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  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

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