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A6751

N-Acetyl-L-tyrosine ethyl ester monohydrate

Name: <I>N</I>-Acetyl-<SC>L</SC>-tyrosine ethyl ester monohydrate
Brand: SIGMA

≥98%, suitable for ligand binding assays

Synonym(s):

ATEE

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₇NO₄ · H₂O

CAS Number:

36546-50-6

Molecular Weight:

269.29

Beilstein:

2217900

EC Number:

212-663-5

MDL number:

MFCD00002389

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24891134

NACRES:

NA.26

product name

N-Acetyl-L-tyrosine ethyl ester monohydrate,

Assay

≥98%

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

SMILES string

CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O

InChI

1S/C13H17NO4/c1-3-18-13(17)12(14-9(2)15)8-10-4-6-11(16)7-5-10/h4-7,12,16H,3,8H2,1-2H3,(H,14,15)/t12-/m0/s1

InChI key

SKAWDTAMLOJQNK-LBPRGKRZSA-N

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Amino Acids

Application

N-Acetyl-L-tyrosine ethyl ester monohydrate has been used:

as a substrate in transesterification reactions with 1 M propan-1-ol catalyzed by Carlsberg protease protein-coated microcrystals (PCMC)
to test the performance of subtilisin Carlsberg protein-coated microcrystals (PCMC)
as a substrate for cross-linked crystals (CLECs) of subtilisin activity screening

Biochem/physiol Actions

N-Acetyl-L-tyrosine ethyl ester is an N-terminal and C-terminal protected L-tyrosine that is used in crosslinking studies and as a substrate for the detection, differentiation and/or characterization various proteases and esterases.

Substrates

Substrate for chymotrypsin

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Operational stability of subtilisin CLECs in organic solvents in repeated batch and in continuous operation

Fernandes JFA, et al.

Biochemical Engineering Journal, 24(1) (24)

Unconjugated bilirubin inhibits C1 esterase activity.

Sandra M Arriaga et al.

Clinical biochemistry, 42(9), 919-921 (2009-01-20)

To evaluate if unconjugated bilirubin (UB) inhibits C1 esterase activity. Esterase activity was evaluated by C1-mediated hydrolysis of N-acetyl-L-tyrosine ethyl ester, and binding of UB to C1r and C1s was assessed by dot-blot analysis. UB inhibited C1 enzymatic activity. C1r

High-activity biocatalysts in organic media: solid-state buffers as the immobilisation matrix for protein-coated microcrystals.

Michaela Kreiner et al.

Biotechnology and bioengineering, 87(1), 24-33 (2004-06-24)

Recently, we reported a new high-activity biocatalyst for use in organic media termed protein-coated microcrystals (PCMC) (Kreiner et al. [2001] Chem Commun 12:1096-1097). These novel particles consist of water-soluble micron-sized crystalline particles coated with the given biocatalyst(s) and are prepared

A study of the intermolecular interactions of tolmetin/N-acetyl-L-tyrosine ethyl ester complex.

Tito A, Jimenez-Lopez C, et al.

Spectrochimica Acta Part A: Molecular Spectroscopy, 72, 1000-1006 (2009)

Stability of protein-coated microcrystals in organic solvents

Kreiner M, et al.

Journal of Molecular Catalysis. B, Enzymatic, 33(3-6) (33)

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