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A6566

2-Hydroxysaclofen

Name: 2-Hydroxysaclofen
Brand: SIGMA

≥98% (TLC), solid

Synonym(s):

3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₂ClNO₄S

CAS Number:

117354-64-0

Molecular Weight:

265.71

NACRES:

NA.32

PubChem Substance ID:

24278170

UNSPSC Code:

12352200

MDL number:

MFCD00069282

Assay:

≥98% (TLC)

Form:

solid

Quality level:

200

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Properties

Quality Level

200

assay

≥98% (TLC)

form

solid

color

white

solubility

H₂O: 1 mg/mL, 0.1 M HCl: 1.2 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M NaOH: 9.5 mg/mL

SMILES string

NCC(O)(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)

InChI key

WBSMZVIMANOCNX-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Description

Biochem/physiol Actions

Potent and selective antagonist at GABA_B receptors.

pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P280 - P305 + P351 + P338 - P310

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

0000554923

0000357420

071M1618V

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Gamma-aminobutyric acid neuropharmacological investigations on narcosis produced by nitrogen, argon, or nitrous oxide.

Jacques H Abraini et al.

Anesthesia and analgesia, 96(3), 746-749 (2003-02-25)

Inhaled anesthetics, including the gaseous anesthetics nitrous oxide and xenon, are thought to act by interacting directly with ion-channel receptors. In contrast, little is known about the mechanism of action of inert gases that show only narcotic potency at high

Effects of GABAB receptor agonists and antagonists on glycemia regulation in mice.

María M Bonaventura et al.

European journal of pharmacology, 677(1-3), 188-196 (2012-01-03)

γ-Aminobutyric acid (GABA) inhibits insulin secretion through GABA(B) receptors in pancreatic β-cells. We investigated whether GABA(B) receptors participated in the regulation of glucose homeostasis in vivo. BALB/c mice acutely pre-injected with the GABA(B) receptor agonist baclofen (7.5mg/kg, i.p.) presented glucose

Synaptic mechanisms regulating the activation of a Ca(2+)-mediated plateau potential in developing relay cells of the LGN.

Fu-Sun Lo et al.

Journal of neurophysiology, 87(3), 1175-1185 (2002-03-06)

Using intracellular recordings in an isolated (in vitro) rat brain stem preparation, we examined the synaptic responses of developing relay neurons in the dorsal lateral geniculate nucleus (LGN). In newborn rats, strong stimulation of the optic tract (OT) evoked excitatory

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Global Trade Item Number

SKU	GTIN
A6566-2.5MG	04061833002001