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A6558

Sigma-Aldrich

L-Aspartic acid potassium salt

≥98% (HPLC), suitable for ligand binding assays

Synonym(s):

Potassium L-aspartate

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About This Item

Linear Formula:
HO2CCH2CH(NH2)CO2K
CAS Number:
1115-63-5
Molecular Weight:
171.19
EC Number:
214-226-4
MDL number:
MFCD00063085
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24891105
NACRES:
NA.77

product name

L-Aspartic acid potassium salt, ≥98% (HPLC)

Quality Level

200

Assay

≥98% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

SMILES string

N[C@H](C([O-])=O)CC(O)=O.[K+]

InChI

1S/C4H7NO4.K/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H,6,7)(H,8,9);/q;+1/p-1/t2-;/m0./s1

InChI key

TXXVQZSTAVIHFD-DKWTVANSSA-M

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General description

L-aspartic acid is a non-essential amino acid.

Application

L-Aspartic acid potassium salt has been used:
  • to prepare perforated patch-clamp intracellular solution
  • in serum glutamate–oxaloacetate transaminase (SGOT) assay
  • as a component in an internal solution (IS) for mitoflash assay to detect mitochondrial flashes in permeabilized cells

Biochem/physiol Actions

L-Aspartic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist.
Potassium aspartate is capable of preventing ventricular arrhythmia in ischemic rabbit heart by decreasing transmural repolarization dispersion (TDR).
Principal neurotransmitter for fast synaptic excitation.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The aim of this study was to determine if the potassium aspartate and magnesium (PAM) prevent reperfusion-induced ventricular arrhythmias (RIVA) in ischemia-reperfusion (IR) rabbit heart. Thirty rabbits were randomly divided into control, ischemia and PAM groups. Arterially-perfused rabbit left ventricular
Qadeer Aziz et al.
Bio-protocol, 10(1), e3478-e3478 (2020-01-05)
Cardiac pacemaker cells of the sino-atrial node are responsible for the initiation of the heart beat and express an array of ion channels. The patch-clamp technique is the gold standard method for investigating the function of ion channels expressed in
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Chromatograms

application for HPLC

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