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A6470

Sigma-Aldrich

N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide

≥97% (HPLC), powder

Synonym(s):

Ac-IEPD-pNA

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About This Item

Empirical Formula (Hill Notation):
C28H38N6O11
CAS Number:
Molecular Weight:
634.63
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥97% (HPLC)

form

powder

solubility

DMSO: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI

1S/C28H38N6O11/c1-4-15(2)24(29-16(3)35)27(42)31-19(11-12-22(36)37)28(43)33-13-5-6-21(33)26(41)32-20(14-23(38)39)25(40)30-17-7-9-18(10-8-17)34(44)45/h7-10,15,19-21,24H,4-6,11-14H2,1-3H3,(H,29,35)(H,30,40)(H,31,42)(H,32,41)(H,36,37)(H,38,39)/t15-,19-,20-,21-,24-/m0/s1

InChI key

YXEIIOVAGGAMCZ-NYMCBPKFSA-N

Amino Acid Sequence

NAc-Ile-Glu-Pro-Asp-pNA

Substrates

Chromogenic substrate for caspase 8 and granzyme B.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Patrick Ho et al.
ACS synthetic biology, 6(8), 1484-1495 (2017-05-17)
Targeted therapies promise to increase the safety and efficacy of treatments against diseases ranging from cancer to viral infections. However, the vast majority of targeted therapeutics relies on the recognition of extracellular biomarkers, which are rarely restricted to diseased cells

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