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A6419

Adenosine 5′-triphosphate disodium salt hydrate

Name: Adenosine 5′-triphosphate disodium salt hydrate
Brand: SIGMA

microbial, BioReagent, suitable for cell culture, ≥99% (HPLC)

Synonym(s):

ATP disodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₅Na₂O₁₃P₃ · xH₂O

CAS Number:

34369-07-8

Molecular Weight:

551.14 (anhydrous basis)

MDL number:

MFCD00150755

UNSPSC Code:

12352207

eCl@ss:

32160414

PubChem Substance ID:

24891086

NACRES:

NA.75

biological source

microbial

Quality Level

200

product line

BioReagent

Assay

≥99% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H₂O: 50 mg/mL

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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Related Categories

Biological Buffers

Phosphates

General description

Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems. They are released from cells under stress and play a key role in immune response. ATP release from injured neurons and consequent breakdown leads to generation of adenosine. ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain. Elevated ATP levels are indicative of cell damage and inflammation.

Application

Adenosine 5′-triphosphate disodium salt hydrate has been used:

as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites
in inflammasome activation assays in bone marrow derived macrophages
for the stimulation of macrophages
in nucleotide synthesis

Biochem/physiol Actions

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Extracellular ATP and adenosine: the Yin and Yang in immune responses?

Faas MM, et al.

Molecular Aspects of Medicine, 55(5), 9-19 (2017)

Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons

Tullius T, et al.

ScienceOpen Research (2018)

Adenosine and its receptors as therapeutic targets: an overview

Sachdeva S and Gupta M

Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society, 21(3), 245-253 (2013)

Effect of interleukin-31 on septic shock through regulating inflammasomes and interleukin-1beta

Gu X, et al.

Experimental and Therapeutic Medicine, 16(1), 171-177 (2018)

Potential value of adenosine 5?-triphosphate (ATP) and adenosine in anaesthesia and intensive care medicine

Skrabanja ATP, et al.

British Journal of Anaesthesia, 94(5), 556-562 (2005)

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