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A5405

Sigma-Aldrich

Avidin-ferritin labeled

avidin egg white, lyophilized powder

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About This Item

MDL number:
UNSPSC Code:
12352203

biological source

avidin from egg white

conjugate

ferritin conjugate

form

lyophilized powder

composition

Protein, ~30%

storage temp.

−20°C

General description

Avidin is homotetrameric protein (68kDa) that is obtained from egg whites. This egg protein binds strongly to biotin. Thus, avidin-biotin association has been utilized in immunoassays to detect the localization of antigens in tissues. The use of avidin-biotin immunoassay enhances the sensitivity of the technique and facilitates the detection of antigens in low quantities.

Application

The product has been used to detect biotin bound to avidin tags in Escherichia coli strains.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing Tris buffer salt

Preparation Note

Labeled with equine spleen ferritin.
Prepared by modification of the procedure of Sullivan, M.J., et al., FEBS Lett., 95, 311 (1978).

Analysis Note

Actual ferritin: avidin ratio given on label.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Richard D Woods et al.
Nano letters, 7(6), 1809-1816 (2007-05-11)
We functionalized Escherichia coli FliC flagellin proteins to form tailored nanotubes binding single types or pairs of ligands, including divalent cations, fluorescent antibodies, or biotin-avidin-linked moieties such as ferritins. The ratio of each tag in bifunctionalized flagella could be toggled
S M Hsu et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 29(4), 577-580 (1981-04-01)
The use of avidin-biotin interaction in immunoenzymatic techniques provides a simple and sensitive method to localize antigens in formalin-fixed tissues. Among the several staining procedures available, the ABC method, which involves an application of biotin-labeled secondary antibody followed by the

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