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Merck
CN

A5285

Adenosine 5′-diphosphate monopotassium salt dihydrate

bacterial, ≥95%, P2Y receptor agonist, powder

Synonym(s):

Adenosine 5′-Diphosphate Potassium Salt, ADP

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About This Item

Empirical Formula (Hill Notation):
C10H14KN5O10P2 · 2H2O
CAS Number:
72696-48-1
Molecular Weight:
501.32
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24890964
NACRES:
NA.77
MDL number:
MFCD00066472

Key Documents

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Product Name

Adenosine 5′-diphosphate monopotassium salt dihydrate, bacterial, ≥95%, powder

SMILES string

[O-]P(OP(OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N2C3=C(N=C2)C(N)=NC=N3)(O)=O)(O)=O.[K+]

InChI

1S/C10H15N5O10P2.K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1

InChI key

ZNCWUOPIJTUALR-MCDZGGTQSA-M

biological source

bacterial

assay

≥95%

form

powder

storage temp.

−20°C

Quality Level

200

Gene Information

human ... HSP90AA1(3320), P2RY1(5028)

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Application

Adenosine 5′-diphosphate has been used to study the release, neuronal effects, and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD+) in the rat brain. Adenosine 5′-diphosphate has also been used to compare prasugrel versus clopidogrel antiplatelet therapy after acute coronary syndrome.
Adenosine 5′-diphosphate monopotassium salt dihydrate (ADP) has been used:
  • in titration to determine complex I-supported respiration in permeabilized muscle fibers
  • in titrations to determine ADP-stimulated respiratory kinetics
  • in the preparation of ADP solution for measuring mitochondrial respiration

General description

Adenosine diphosphate (ADP) is a crucial component for energy flow in living organisms. Its structure consists of a sugar backbone connected to adenine and two phosphate groups attached to the fifth carbon atom of the ribose sugar. ADP serves a precursor for ATP biosynthesis. ADP acts as a weak platelet agonist, specifically targeting the P2Y receptor. However, ADP plays a vital role in platelet function by enhancing the effects of other platelet agonists and promoting the stability of platelet aggregates when released from platelet dense granules.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000482998
0000482998
0000462150
0000462150
0000450506

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Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity
Hardee JP, et al.
Molecular Metabolism (2021)
The Platelet P2 Receptors
Cattaneo M
Platelets (2013)
Daniel S Ziemianowicz et al.
Journal of the American Society for Mass Spectrometry, 31(2), 207-216 (2020-02-08)
The functional properties of a protein are strongly influenced by its topography, or the solvent-facing contour map of its surface. Together with crosslinking, covalent labeling mass spectrometry (CL-MS) has the potential to contribute topographical data through the measurement of surface
Roles of AMP, ADP, ATP, and AMPK in Healthy Energy Boosting and Prolonged Life Span
Yadav D , et al.
Chemistry & Biology (2017)
James E Tcheng et al.
American journal of cardiovascular drugs : drugs, devices, and other interventions, 12(2), 83-91 (2012-02-10)
Antithrombotic therapy is imperative in the management of patients presenting with an acute coronary syndrome (ACS). The combination of antiplatelet therapy in conjunction with antithrombotic therapy has become the standard of care in improving the morbidity and mortality of patients
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