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Safety Information

A5230

Sigma-Aldrich

Anti-ARF6 antibody, Mouse monoclonal

clone ARFAG, purified from hybridoma cell culture

Synonym(s):

ARF6 Antibody - Anti-ARF6 antibody, Mouse monoclonal, Arf6 Antibody, Anti-ADP-Ribosylation Factor 6

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¥5,282.92

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About This Item

MDL number:
MFCD08705572
UNSPSC Code:
12352203
NACRES:
NA.41

¥5,282.92

Please contact Customer Service for Availability
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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

ARFAG, monoclonal

form

buffered aqueous solution

mol wt

antigen 18 kDa

species reactivity

bovine, canine, rat, human

concentration

2 mg/mL

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Gene Information

mouse ... Timp1(21857)

Gene Information

mouse ... Timp1(21857)

Gene Information

mouse ... Timp2(21858)

Gene Information

human ... TIMP1(7076)

species reactivity

mouse

species reactivity

mouse

species reactivity

mouse

species reactivity

human

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 3 pg/mL
standard curve range: 1.37-1000 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 3 pg/mL
standard curve range: 1.37-1000 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 0.0823-60 ng/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 30 pg/mL
standard curve range: 24.69-18000 pg/mL

input

sample type cell culture supernatant(s)
sample type plasma
sample type serum

input

sample type cell lysate
sample type tissue lysate

input

sample type cell culture supernatant(s)
sample type plasma
sample type serum

input

sample type tissue lysate
sample type cell lysate

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

ARF6 is a member of the ADP-ribosylation factor (ARF) family. It is specifically involved in endocytosis of plasma membrane proteins.
Anti-ARF6 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma ARFAG produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a synthetic peptide. class III includes only human Arf6. The ADP-ribosylation factors (Arf) family of proteins, which belong to the Ras (rat sarcoma viral oncogene homolog) family, are low molecular weight proteins capable of binding GTP.

Application

Anti-ARF6 antibody, Mouse monoclonal has been used in:
  • western blotting
  • enzyme linked immunosorbent assay (ELISA)
  • immunocytochemistry

Mouse Monoclonal Anti-ARF6 antibody can be used for western blot assays at 1-2μg/ml using MDCK cell extracts. The antibody can also be used for ELISA and immunocytochemistry.

Biochem/physiol Actions

ADP-ribosylation factor 6 (Arf6) is present at the plasma membrane and on endosomal membranes where it regulates the flow of trafficking into and out of the cell, and regulates the actin cytoskeleton on the plasma membrane. ARF6 activates phospholipase D (PLD) and phosphatidylinositol 4-phosphate 5-kinase (PIP5K) to generate phosphatidic acid and PIP2 (phosphotidylinositol 4,5-bisphosphate), respectively.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000199540
    0000152788
    0000199540
    0000152788
    128M4782V

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    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

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    The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans
    Gonzalez DA, et al.
    Molecular Psychiatry, 23(3), 621-621 (2018)
    Multiple Roles for Arf6: Sorting, Structuring, and Signaling at the Plasma Membrane
    Donaldson JG
    The Journal of biological chemistry, 278(43), 41573-41576 (2003)
    D A Gonzalez et al.
    Molecular psychiatry, 23(3), 621-628 (2017-06-14)
    Ubiquitously expressed genes have been implicated in a variety of specific behaviors, including responses to ethanol. However, the mechanisms that confer this behavioral specificity have remained elusive. Previously, we showed that the ubiquitously expressed small GTPase Arf6 is required for
    Summer F Acevedo et al.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(46), 15396-15402 (2015-11-21)
    Alcohol use disorders (AUDs) affect people at great individual and societal cost. Individuals at risk for AUDs are sensitive to alcohol's rewarding effects and/or resistant to its aversive and sedating effects. The molecular basis for these traits is poorly understood.
    Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse
    Tagliatti E, et al.
    eLife, 5, e10116-e10116 (2016)
    View All Related Papers

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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