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Safety Information

A5095

Sigma-Aldrich

N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin

≥97% (HPLC), powder

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Synonym(s):
Ac-VEID-AFC
Linear Formula:
C32H40N5O11F3
Molecular Weight:
727.68
MDL number:
MFCD01318833
UNSPSC Code:
12352209
PubChem Substance ID:
329770866
NACRES:
NA.32

Quality Level

200

Assay

≥97% (HPLC)

form

powder

solubility

DMSO/DMF: 20 mM

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI

1S/C38H44F3N5O12/c1-5-20(4)32(36(55)44-26(17-29(49)50)34(53)42-22-11-12-23-24(38(39,40)41)16-30(51)58-27(23)15-22)45-33(52)25(13-14-28(47)48)43-35(54)31(19(2)3)46-37(56)57-18-21-9-7-6-8-10-21/h6-12,15-16,19-20,25-26,31-32H,5,13-14,17-18H2,1-4H3,(H,42,53)(H,43,54)(H,44,55)(H,45,52)(H,46,56)(H,47,48)(H,49,50)/t20-,25-,26-,31-,32-/m0/s1

InChI key

OEVAAZFKVRJQQH-UXAYAQJLSA-N

Gene Information

human ... CASP6(839)

Amino Acid Sequence

NAc-Val-Glu-Ile-Asp-AFC

Biochem/physiol Actions

Fluorogenic substrate for caspase 6 (Mch-2α).

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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A Takahashi et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(16), 8395-8400 (1996-08-06)
Although proteases related to the interleukin 1 beta-converting enzyme (ICE) are known to be essential for apoptotic execution, the number of enzymes involved, their substrate specificities, and their specific roles in the characteristic biochemical and morphological changes of apoptosis are
Ilona Domracheva et al.
Life sciences, 186, 92-101 (2017-08-16)
This study was designed to investigate the mechanism underlying cancer cell apoptosis caused by selenophenoquinolinones and coumarins. Twelve derivatives were studied according to their ability to suppress the proliferation of cancer cells in vitro (i.e., HepG2, MH-22A, MCF-7), induce cell
R V Talanian et al.
The Journal of biological chemistry, 272(15), 9677-9682 (1997-04-11)
The caspase family represents a new class of intracellular cysteine proteases with known or suspected roles in cytokine maturation and apoptosis. These enzymes display a preference for Asp in the P1 position of substrates. To clarify differences in the biological

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