A5043
Adenosine Deaminase from bovine spleen
Type X, buffered aqueous glycerol solution, ≥130 units/mg protein
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ADA, adenosine aminohydrolase, Adenosine aminohydrolase
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biological source
bovine spleen
Quality Level
type
Type X
form
buffered aqueous glycerol solution
specific activity
≥130 units/mg protein
mol wt
32.5-33 kDa
cation traces
NH4+: ≤10 μg/mg protein
UniProt accession no.
foreign activity
alkaline phosphatase ≤0.01%
guanase ≤0.01%
nucleoside phosphorylase ≤0.1%
storage temp.
2-8°C
Gene Information
cow ... ADA(280712)
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General description
Molecular weight: 32.5-33 kDa
pI: 4.85
pI: 4.85
Application
Adenosine Deaminase from bovine spleen has been used in the immobilization on biostrip for stability and catalytic studies.
Adenosine deaminase is useful in various molecular biology assays, such as glycerol release assays . Adenosine deaminase is a potential target for treatments of combined immunodeficiency disease.
Biochem/physiol Actions
Adenosine deaminase is a purine catabolic enzyme which catalyzes the deamination of adenosine and 2′-deoxyadenosine with approximately equal specificity. It is ubiquitous in mammalian tissue, and deficiency in adenosine deaminase has been associated with severe combined immunodeficiency disease.
Unit Definition
One unit will deaminate 1.0 μmole of adenosine to inosine per min at pH 7.5 at 25 °C.
Physical form
Solution in 50% glycerol, 5 mM potassium phosphate, pH 6.0
Analysis Note
Protein determined by biuret.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
动植物源性产品
Certificates of Analysis (COA)
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Adenosine reagent-free detection by co-immobilization of adenosine deaminase and phenol red on an optical biostrip
Biotechnology Journal, 10(1), 136-142 (2015)
Diabetes, 59(1), 17-25 (2009-10-17)
White adipose tissue (WAT) and brown adipose tissue (BAT) play distinct roles in adaptation to changes in nutrient availability, with WAT serving as an energy store and BAT regulating thermogenesis. We previously showed that mice maintained on a leucine-deficient diet
Neutropenia and myeloid dysplasia in a patient with delayed-onset adenosine deaminase deficiency.
Pediatric blood & cancer, 60(5), 885-886 (2013-01-22)
Nucleic acids research, 41(4), 2581-2593 (2013-01-01)
RNA editing by adenosine deaminases that act on RNA (ADARs) diversifies the transcriptome by changing adenosines to inosines. In mammals, editing levels vary in different tissues, during development, and also in pathogenic conditions. From a screen for repressors of editing
Investigacion clinica, 53(3), 315-324 (2012-12-20)
Adenosine deaminase is an enzyme of the purine metabolism whose function is to convert adenosine to inosine and deoxyadenosine to deoxyinosine. The ecto-ADA1 binding to the cell surface through CD26 contributes to the regulation of cytokines and stimulates the proliferation
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