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A4685

Luminol sodium salt

Name: Luminol sodium salt
Brand: SIGMA

luminescent, ≥98% (titration), powder and chunks

Synonym(s):

3-Aminophthalhydrazide, 5-Amino-2,3-dihydro-1,4-phthalazinedione

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About This Item

Linear Formula:

C₈H₆N₃O₂Na

CAS Number:

20666-12-0

Molecular Weight:

199.14

MDL number:

MFCD00161491

UNSPSC Code:

12352204

PubChem Substance ID:

24890898

NACRES:

NA.83

product name

Luminol sodium salt,

Assay

≥98% (titration)

Quality Level

300

form

powder and chunks

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to faint red

SMILES string

O=C1NN([Na])C(C2=CC=CC(N)=C21)=O

InChI

1S/C8H7N3O2.Na/c9-5-3-1-2-4-6(5)8(13)11-10-7(4)12;/h1-3H,(H4,9,10,11,12,13);/q;+1/p-1

InChI key

RVJVDCVIJCBUTH-UHFFFAOYSA-M

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Application

Luminol sodium salt has been used:

as a component of MEBSS buffer in a bioluminescence assay to detect peroxidase activity in whole blood samples
to study protein interaction in whole-cell lysates by immunoprecipitation
for in vitro reactive oxygen species (ROS) quantification in CD45⁺ and CD45− cells

Biochem/physiol Actions

Luminol is a redox-sensitive chemiluminescent compound. It emits blue luminescence when the basic aqueous solution of luminol having oxygen atoms come in contact with oxidizing agents like potassium ferricyanide. It is highly stable and is applicable in various fields such as analytical chemistry, metallurgy, biochemistry, and forensics for detecting reactive species. Luminol has the potential to detect defects in neutrophils ex vivo during oxidative metabolism defects such as chronic granulomatous disease and myeloperoxidase deficiency.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Opioids prevent regeneration in adult mammals through inhibition of ROS production

Elodie L, et al.

Scientific Reports, 8(1) (2018)

Chemiluminescence detection in analytical chemistry

Lancaster, J. Steven

Endeavour, 16, 194-194 (1992)

Detection of glucocorticoid residues in pig liver by high-performance liquid chromatography with on-line electrogenerated [Cu(HIO6)2](5-)--luminol chemiluminescence detection.

Yantu Zhang et al.

Journal of chromatography. A, 1154(1-2), 260-268 (2007-04-24)

A novel method was developed for the simultaneous determination of glucocorticoid residues such as triamcinolone (TR), prednisolone (PR), hydrocortisone (HC), cortisone (CO), methylprednisolone (MP), dexamethasone (DE) and triamcinolone acetonide (TA) by high-performance liquid chromatography (HPLC) coupled with chemiluminescence (CL) detection.

New Developments in Chemiluminescence Research

Gill, Steven, K.

Aldrichimica Acta, 16, 59-59 (1983)

Chemilunimescence of luminol: The chemcial reaction

White E H, et al.

ACS Chemical Biology, 86(5), 940-941 (1964)

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