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A4534

Sigma-Aldrich

L-Aspartic acid

BioReagent, suitable for cell culture, suitable for insect cell culture

Synonym(s):

(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid

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About This Item

Linear Formula:
HO2CCH2CH(NH2)CO2H
CAS Number:
56-84-8
Molecular Weight:
133.10
Beilstein:
1723530
EC Number:
200-291-6
MDL number:
MFCD00002616
UNSPSC Code:
12352200
eCl@ss:
32160406
PubChem Substance ID:
24890873

product line

BioReagent

Assay

≥98% (TLC)

form

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

color

white to off-white

mp

>300 °C (dec.) (lit.)

SMILES string

N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

InChI key

CKLJMWTZIZZHCS-REOHCLBHSA-N

Gene Information

human ... CA1(759) , CA2(760)
rat ... Grin2a(24409)

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Biochem/physiol Actions

Principal neurotransmitter for fast synaptic excitation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
050M0161V
036K00842
BCBD5156V
BCBD5156
BCBC7840V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What can I use to solubilize L-Aspartic acid, Product A4534?

    This product is soluble in water at a concentration of 5mg/mL. Sigma has tested this product in 0.5M hydrochloric acid at a concentration of 50mg/mL, yielding a clear, colorless to faint yellow solution.

  6. The description of L-Aspartic acid, Product A4534, says that it is "cell culture tested". What does that mean for this product?

    Growth studies are carried through two subculture generations at 0.133 mg/mL. Cells are counted and growth is plotted as a logarithmic function of time in culture. Seeding efficiencies, doubling time, and final cell densities are determined. During the testing period, cultures are examined microscopically for atypical morphology and evidence of cytotoxicity.

  7. What is the shelf life of L-Aspartic acid, Product A4534?

    There is no expiration date or recommended retest date for this product. We will guarantee the product for one year from the date of shipment.

  8. Do you have any solution stability information for Product A4534, L-Aspartic acid?

    L-aspartic acid may be used in cell culture media from 0.00665 g/L up to 0.05 g/L.  Most cell culture media has a minimum shelf life of 1 year at 2-8°C.  A stock solution at 50 mg/mL should be stable at least 6 months at 2-8°C

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Robert B Campenot et al.
Nature protocols, 4(12), 1869-1887 (2009-12-17)
The compartmented culture, in which primary neurons plated in a proximal compartment send their axons under silicone grease barriers and into left and right distal compartments, has enhanced the experimental capabilities of neuronal cultures. Treatments can be applied separately to
Guus B Erkens et al.
Nature, 502(7469), 119-123 (2013-10-05)
Excitatory amino acid transporters (EAATs) are secondary transport proteins that mediate the uptake of glutamate and other amino acids. EAATs fulfil an important role in neuronal signal transmission by clearing the excitatory neurotransmitters from the synaptic cleft after depolarization of
Ann-Louise Johansson et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8912-8917 (2013-05-16)
Proton transfer across biological membranes underpins central processes in biological systems, such as energy conservation and transport of ions and molecules. In the membrane proteins involved in these processes, proton transfer takes place through specific pathways connecting the two sides
Tamami Uejima et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 3), 345-351 (2013-03-23)
Rab small GTPases regulate vesicle transport in eukaryotes by interacting with various effectors. Guanine nucleotide-exchange factor (GEF) catalyzes the transition from inactive GDP-bound Rab to active GTP-bound Rab. The existence of several GDP-bound intermediates containing the Arabidopsis thaliana Rab5 homologue
Yoshikatsu Kanai et al.
Molecular aspects of medicine, 34(2-3), 108-120 (2013-03-20)
Glutamate transporters play important roles in the termination of excitatory neurotransmission and in providing cells throughout the body with glutamate for metabolic purposes. The high-affinity glutamate transporters EAAC1 (SLC1A1), GLT1 (SLC1A2), GLAST (SLC1A3), EAAT4 (SLC1A6), and EAAT5 (SLC1A7) mediate the
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