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Merck
CN

A3913

L-Argininamide dihydrochloride

≥98%, suitable for ligand binding assays

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About This Item

Empirical Formula (Hill Notation):
C6H15N5O · 2HCl
CAS Number:
14975-30-5
Molecular Weight:
246.14
UNSPSC Code:
12352209
PubChem Substance ID:
24890827
NACRES:
NA.26
MDL number:
MFCD00058286

Key Documents

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Product Name

L-Argininamide dihydrochloride,

SMILES string

Cl.N[C@@H](CCCNC(N)=N)C(N)=O

InChI

1S/C6H15N5O.ClH/c7-4(5(8)12)2-1-3-11-6(9)10;/h4H,1-3,7H2,(H2,8,12)(H4,9,10,11);1H/t4-;/m0./s1

InChI key

BPQLYFCEVVKLLX-WCCKRBBISA-N

assay

≥98%

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

Quality Level

200

Related Categories

Application

L-Argininamide dihydrochloride has been used as an additive to compare its effect over L-arg in egg lysozyme refolding studies. It has also been used as a component of substrate stock solution for enzymatic kyotorphin synthesis.

Biochem/physiol Actions

L-Argininamide (L-Arm) is a hydrophilic amino acid derivative that is used as a model compound in physicochemical characteristic studies of ligand binding DNA aptamers and their potential development as fluorescent aptasensors.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

hcodes

H302,H370

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 1

target_organs

Eyes

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK8934
BCCF9587
BCBV9948
BCBQ1412V
BCBQ1412

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Max Keller et al.
Journal of medicinal chemistry, 51(24), 8168-8172 (2008-12-05)
Synthesis and characterization of (R)-N(alpha)-(2,2-diphenylacetyl)-N-(4-hydroxybenzyl)-N(omega)-([2,3-(3)H]-propanoyl)argininamide ([(3)H]-UR-MK114), an easily accessible tritium-labeled NPY Y(1) receptor (Y(1)R) antagonist (K(B): 0.8 nM, calcium assay, HEL cells) derived from the (R)-argininamide BIBP 3226, is reported. The radioligand binds with high affinity (K(D), saturation: 1.2 nM
Xinhua Guo et al.
Analytical chemistry, 78(20), 7259-7266 (2006-10-14)
The 24-mer DNA aptamer of Harada and Frankel (Harada, K.; Frankel, A. D. EMBO J. 1995, 14, 5798-5811) that binds L-argininamide (L-Arm) was studied by electrospray ionization Fourier transform mass spectrometry (ESI-FTMS). This DNA folds into a stem and loop
Razvan Nutiu et al.
Methods (San Diego, Calif.), 37(1), 16-25 (2005-10-04)
Aptamers are single-stranded DNA or RNA molecules with ligand-binding capabilities. Signaling aptamers refer to aptamers or modified aptamers with recordable signal generation ability. Fluorescence-signaling aptamers, in particular, are valuable molecular tools that can be used to establish important techniques or
Stefan Weiss et al.
Bioorganic & medicinal chemistry, 18(17), 6292-6304 (2010-08-07)
N(G)-Acylated argininamides, covering a broad range of lipophilicity (calculated logD values: -1.8-12.5), were synthesized and investigated for NPY Y(1) receptor (Y(1)R) antagonism, Y(1)R affinity and stability in buffer (N(G)-deacylation, yielding BIBP 3226). Broad structural variation of substituents was tolerated. The
Hiroyuki Hamada et al.
Journal of biotechnology, 130(2), 153-160 (2007-04-17)
L-arginine (Arg) is a widely used additive for suppressing protein aggregation during refolding. Systematic screening of Arg analogs provides superior additives that enhance the refolding yield more effectively than Arg. The refolding yield of hen egg lysozyme in the presence
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