All Photos(2)
Synonym(s):
BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)
Empirical Formula (Hill Notation):
C284H432N84O79S7
CAS Number:
Molecular Weight:
6511.44
EC Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
biological source
bovine lung
Quality Level
form
powder
mol wt
~6,500
packaging
vial of 15 mg
solubility
glycerol: 3 mg/mL, clear, colorless (equilibration buffer containing 5% glycerol)
UniProt accession no.
storage temp.
−20°C
InChI key
ZPNFWUPYTFPOJU-UHFFFAOYSA-N
Gene Information
cow ... PTI(404172)
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Application
Aprotinin is largely used as an inhibitor of trypsin.
Gel filtration molecular weight marker
Biochem/physiol Actions
Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.
Unit Definition
One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
动植物源性产品
Certificates of Analysis (COA)
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Yimin Yao et al.
International journal of molecular sciences, 23(10) (2022-05-29)
Systemic sclerosis (SSc) is characterised by progressive multiple organ fibrosis leading to morbidity and mortality. Lysyl oxidases play a vital role in the cross-linking of collagens and subsequent build-up of fibrosis in the extracellular matrix. As such, their inhibition provides
Ishita Chandel et al.
Bio-protocol, 13(18), e4827-e4827 (2023-09-27)
Matriglycan is a linear polysaccharide of alternating xylose and glucuronic acid units [-Xyl-α1,3-GlcA-β1,3]n that is uniquely synthesized on α-dystroglycan (α-DG) and is essential for neuromuscular function and brain development. It binds several extracellular matrix proteins that contain laminin-globular domains and
Zbigniew Dauter
Acta crystallographica. Section D, Biological crystallography, 69(Pt 1), 2-4 (2013-01-01)
To uniquely describe a crystal structure, it is sufficient to specify the crystal unit cell and symmetry, and describe the unique structural motif which is repeated by the space-group symmetry throughout the whole crystal. It is somewhat arbitrary how such
Bernhard Glotzbach et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 1), 114-120 (2013-01-01)
In recent decades, several canonical serine protease inhibitor families have been classified and characterized. In contrast to most trypsin inhibitors, those from garden four o'clock (Mirabilis jalapa) and spinach (Spinacia oleracea) do not share sequence similarity and have been proposed
Yong Fan et al.
Paediatric anaesthesia, 23(3), 242-249 (2012-11-30)
The great difference in side effects of aprotinin was noted in adult and pediatric fields in recent reports because aprotinin was suspended for safety reasons. The aim of this study is to describe associations between aprotinin using and red blood
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