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Merck
CN

A2900

[Val5]-Angiotensin II acetate salt hydrate

≥95% (HPLC), angiotensin II type 1 receptor agonist, powder

Synonym(s):

Angiotensin II Acetate

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About This Item

Empirical Formula (Hill Notation):
C49H69N13O12 · xC2H4O2 · yH2O
Molecular Weight:
1032.15 (anhydrous free base basis)
UNSPSC Code:
12352209
PubChem Substance ID:
329770803
NACRES:
NA.77

Key Documents

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Product Name

[Val5]-Angiotensin II acetate salt hydrate, ≥95% (HPLC), powder

SMILES string

O.CC(O)=O.CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C49H69N13O12.C2H4O2.H2O/c1-26(2)39(60-42(67)33(12-8-18-54-49(51)52)56-41(66)32(50)23-38(64)65)45(70)57-34(20-29-14-16-31(63)17-15-29)43(68)61-40(27(3)4)46(71)58-35(22-30-24-53-25-55-30)47(72)62-19-9-13-37(62)44(69)59-36(48(73)74)21-28-10-6-5-7-11-28;1-2(3)4;/h5-7,10-11,14-17,24-27,32-37,39-40,63H,8-9,12-13,18-23,50H2,1-4H3,(H,53,55)(H,56,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,64,65)(H,73,74)(H4,51,52,54);1H3,(H,3,4);1H2/t32-,33-,34-,35-,36-,37-,39-,40-;;/m0../s1

InChI key

INQPQDZJLFYCRH-AXOAQIBVSA-N

assay

≥95% (HPLC)

form

powder

composition

acetate, 1.2-10.4%

storage temp.

−20°C

Quality Level

200

Gene Information

human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180)

Related Categories

General description

[Val5]-Angiotensin II ([Val5]-ANG II) is an ANG II analog containing valine as the fifth amino acid in place of isoleucine in an ANG II octapeptide.

Application

[Val5]-Angiotensin II acetate salt hydrate has been used to induce:
  • renal damage in mice to study the role of human liver-type fatty acid-binding protein (hL-FABP)
  • vascular inflammation in mice to study the interaction of cytosolic copper chaperone antioxidant-1 (Atox1) with tumor necrosis factor (TNF)-receptor-associated factor 4 (TRAF4)
  • abdominal aortic aneurysm (AAA) in mice to study the role of vascular ATPase copper transporting α (ATP7α)

Biochem/physiol Actions

[Val5]-Angiotensin II acts as an agonist for the angiotensin II type 1 receptor (AT1 receptor).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000481317
0000481317
0000443459
0000443459
0000441480

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Archita Das et al.
American journal of physiology. Cell physiology, 317(6), C1161-C1171 (2019-09-26)
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, have been implicated in vascular inflammatory diseases. We reported that in proinflammatory cytokine TNF-α-stimulated endothelial cells (ECs), cytosolic Cu chaperone antioxidant-1 (Atox1) functions as a Cu-dependent transcription
Yuhan Chen et al.
Cardiovascular research, 117(4), 1217-1228 (2020-07-02)
Elevated serum immunoglobulins have been associated with experimental and human hypertension for decades but whether immunoglobulins and B cells play a causal role in hypertension pathology is unclear. In this study, we sought to determine the role of B cells
D G Butler et al.
Archives internationales de pharmacodynamie et de therapie, 329(2), 272-282 (1995-03-01)
Pressor responses to [Ile5]-Angiotensin II and [Val5]-Angiotensin II were measured following single intravenous doses of 0.0075, 0.075, 0.375, 0.75 and 7.5 micrograms/kg b.w. in anesthetised rats. [Val5]-Angiotensin II was significantly (10 per cent) more potent than [Ile5]-angiotensin II when log
Daisuke Ichikawa et al.
Hypertension (Dallas, Tex. : 1979), 60(4), 973-980 (2012-08-29)
To investigate the role of human liver-type fatty acid binding protein (hL-FABP) in angiotensin (Ang) II-induced renal injury, Ang II was infused systemically into hL-FABP chromosomal transgenic (Tg) and wild-type (WT) mice (Tg-Ang II and WT-Ang II) for 28 days.
H Fujioka et al.
The Tohoku journal of experimental medicine, 177(3), 183-192 (1995-11-01)
We investigated the degradation of angiotensin II by vascular endothelial cells and smooth muscle cells in vitro. When angiotensin II was incubated with confluent culture of endothelial cells or with serum free conditioned medium of the endothelial cells, angiotensin II
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