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Merck
CN

A2661

Acetylcholine chloride

suitable for cell culture

Synonym(s):

ACh

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About This Item

Linear Formula:
(CH3)3N+CH2CH2OCOCH3Cl-
CAS Number:
60-31-1
Molecular Weight:
181.66
NACRES:
NA.75
PubChem Substance ID:
24890686
eCl@ss:
32190102
UNSPSC Code:
12352209
EC Number:
200-468-8
MDL number:
MFCD00011698
Beilstein/REAXYS Number:
3571875
Biological source:
synthetic
Form:
powder
Assay:
~99%

Key Documents

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Product Name

Acetylcholine chloride, suitable for cell culture

InChI key

JUGOREOARAHOCO-UHFFFAOYSA-M

InChI

1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

SMILES string

[Cl-].CC(=O)OCC[N+](C)(C)C

biological source

synthetic

assay

~99%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

146-150 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... CHRM3(1131)

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Related Categories

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.

Application

Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN7455
BCCM2700
BCCH5244
BCCD7863
BCBZ6218

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A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing
Sletten D M, et al.
Autonomic Neuroscience : Basic & Clinical, 150(1-2), 127-130 (2009)
Yue-Chen Chang et al.
Kidney & blood pressure research, 43(5), 1607-1622 (2018-10-23)
This experimental study aims to observe whether the protective effect of propofol against renal ischemia-reperfusion injury (IRI) in the rat interlobar artery occurs through altered expression of the gap junction protein connexin 43 (Cx43). This study randomly divided male Sprague
Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates
Garavaglia A, et al.
BMC Neuroscience, 11(1), 7-7 (2010)
Fabian Hertel et al.
ACS chemical biology, 15(1), 33-38 (2019-12-20)
Phosphoinositides constitute a critical family of lipids that regulate numerous cellular processes. Phosphatidylinositol 4,5-bisphosphate (PIP2) is arguably the most important plasma membrane phosphoinositide and is involved in regulating diverse processes. It is also the precursor of phosphatidylinositol 3,4,5-trisphosphate (PIP3), which
Wei Shi et al.
The Journal of biological chemistry, 295(22), 7653-7668 (2020-04-24)
The erythropoietin-producing human hepatocellular receptor EPH receptor B6 (EPHB6) is a receptor tyrosine kinase that has been shown previously to control catecholamine synthesis in the adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent fashion. EPHB6 also has a role in
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