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A2661

Sigma-Aldrich

Acetylcholine chloride

suitable for cell culture

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Synonym(s):
ACh
Linear Formula:
(CH3)3N+CH2CH2OCOCH3Cl-
CAS Number:
60-31-1
Molecular Weight:
181.66
Beilstein:
3571875
EC Number:
200-468-8
MDL number:
MFCD00011698
UNSPSC Code:
12352209
eCl@ss:
32190102
PubChem Substance ID:
24890686
NACRES:
NA.75

biological source

synthetic

Quality Level

200

Assay

~99%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

146-150 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

[Cl-].CC(=O)OCC[N+](C)(C)C

InChI

1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

InChI key

JUGOREOARAHOCO-UHFFFAOYSA-M

Gene Information

human ... CHRM3(1131)

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Application

Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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