A2562
Angiotensinogen from human plasma
≥80% (SDS-PAGE)
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Synonym(s):
Hypertensinogen, Renin substrate
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Biochem/physiol Actions
Angiotensinogen (renin substrate), a component of the rennin-angiotensin system, is a precursor protein to a family of blood pressure and hormone release regulating peptides known as the angiotensins.
Packaging
Package size based on protein content.
Physical form
Lyophilized powder containing sodium phosphate buffer, pH 7.
Analysis Note
Protein determined by A1%/280
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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O von Bohlen und Halbach
Current protein & peptide science, 6(4), 355-371 (2005-08-17)
The brain renin-angiotensin system enables the formation of different biological active forms of angiotensins within the brain. All enzymes and peptides necessary for the biosynthesis of these angiotensins have been recognized within the central nervous system. Since there are considerable
R T Radulescu
Bioscience trends, 6(6), 340-341 (2013-01-23)
Hypertension ranks among the most important disease challenges on a global scale. Here, a novel hypothesis is presented which implicates angiotensinogen, i.e. the precursor protein for the hypertensive peptide angiotensin II, as a key culprit in the pathogenesis of hypertension.
Jie Yang et al.
Journal of molecular endocrinology, 50(2), R53-R66 (2013-02-02)
The compensatory alterations in the rennin-angiotensin-aldosterone system (RAAS) contribute to the salt-water balance and sufficient placental perfusion for the subsequent well-being of the mother and fetus during normal pregnancy and is characterized by an increase in almost all the components
Angiotensinogen gene polymorphism and HDL2 are linked to coronary artery calcification in individuals with family history of early coronary disease.
Andrei C Sposito et al.
Atherosclerosis, 226(2), 339-340 (2013-01-01)
Lodi C W Roksnoer et al.
Current hypertension reports, 15(2), 81-88 (2013-01-09)
Recent interest focuses on urinary renin and angiotensinogen as markers of renal renin-angiotensin system activity. Before concluding that these components are independent markers, we need to exclude that their presence in urine, like that of albumin (a protein of comparable
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