A2559
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide
≥97% (HPLC), powder
Synonym(s):
Ac-DEVD-pNA
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About This Item
Empirical Formula (Hill Notation):
C26H34N6O13
CAS Number:
Molecular Weight:
638.58
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Quality Level
assay
≥97% (HPLC)
form
powder
color
white
storage temp.
−20°C
SMILES string
CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O
InChI
1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1
InChI key
GGXRLUDNGFFUKI-ORGXJRBJSA-N
Gene Information
human ... CASP3(836)
Application
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.
Biochem/physiol Actions
Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Hui-Fang Jin et al.
Frontiers in cell and developmental biology, 8, 555937-555937 (2020-10-20)
MicroRNAs (miRNAs) are dysregulated in the context of many cancer types, making them potentially ideal diagnostic or therapeutic targets in patients in which they are aberrantly expressed. In the present study, we found miR-7 to be downregulated in gastric cancer
Nrf2 protects against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis.
Lu H, et al.
Toxicology and Applied Pharmacology, 256(2), 122-135 (2011)
Ouyang Chen et al.
Scientific reports, 7(1), 14871-14871 (2017-11-03)
The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH). C57BL/6 mice were randomly divided into the following groups: sham, I/R, I/R + HCH, I/R + HCH + LY294002 (PI3K inhibitor), I/R + HCH + wortmannin (PI3K inhibitor), I/R + LY294002, and I/R + wortmannin. After 45 min of ischemia, HCH
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2559-1MG | 04061823596954 |
| A2559-15MG | 04061832776033 |
| A2559-5MG | 04061833352236 |