Skip to Content
Merck
CN

A255

A-77636 hydrochloride hydrate

≥98% (HPLC), solid

Synonym(s):

(−)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C20H27NO3 · HCl · xH2O
CAS Number:
145307-34-2
Molecular Weight:
365.89 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24277883
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated
protect from light

color

white to off-white

solubility

H2O: >10 mg/mL

storage temp.

−20°C

SMILES string

O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4

InChI

1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1

InChI key

KNACNUUSUYTFDY-LIWDBWMRSA-N

Gene Information

human ... DRD1(1812)

Related Categories

Biochem/physiol Actions

Potent, orally active D1 dopamine receptor agonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold under exclusive license from Abbott Laboratories.

Disclaimer

Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
011M4604V
0000064628
097K46051
097K4605
073K461411

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ales Stuchlik et al.
Behavioural brain research, 172(2), 250-255 (2006-06-20)
Central dopamine neurotransmission is implicated in several physiological and pathophysiological neural processes. In the past years, attention was paid to the role of dopaminergic signaling in the cognitive processes. In the present study, we investigate role of dopamine D1 receptors
D Wirtshafter
Synapse (New York, N.Y.), 28(2), 154-159 (1998-02-05)
Systemic injections of the selective, full, D1 agonists A-77636 and SKF-82958 induced pronounced Fos-like immunoreactivity in the islands of Calleja in the olfactory tubercle of intact rats. Fos expression in this region could also be induced by injections of the
E Acquas et al.
Journal of neurochemistry, 70(3), 1088-1093 (1998-03-07)
This study examined the effects of different levels of acetylcholinesterase (AChE) inhibition on dopaminergic regulation of striatal acetylcholine (ACh) release as estimated by in vivo brain microdialysis. Systemic administration of d-amphetamine (2 or 10 mg/kg) increased the striatal output of
J X Cai et al.
The Journal of pharmacology and experimental therapeutics, 283(1), 183-189 (1997-10-23)
With advancing age, monkeys develop deficits in spatial working memory resembling those induced by lesions of the prefrontal cortex (PFC). Aged monkeys also exhibit marked loss of dopamine from the PFC, a transmitter known to be important for proper PFC
Amy F T Arnsten et al.
Biological psychiatry, 57(11), 1377-1384 (2005-06-14)
The prefrontal cortex guides behaviors, thoughts, and feelings using representational knowledge, i.e., working memory. These fundamental cognitive abilities subserve the so-called executive functions: the ability to inhibit inappropriate behaviors and thoughts, regulate our attention, monitor our actions, and plan and
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service