A211630
DMT-2′O-TC-rA(bz) Phosphoramidite
configured for ABI
Synonym(s):
N6-Benzoyl-O5′-(4,4′-dimethoxytrityl)-O2′-(1,1-dioxothiomorpholine-4-thiocarbonyl)adenosine O3′-(O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite)
About This Item
product line
Proligo Reagents
Assay
≥98% (31P-NMR)
≥98.0% (reversed phase HPLC)
form
solid
technique(s)
oligo synthesis: suitable
impurities
≤0.3 wt. % water content (Karl Fischer)
≤0.5% 3′-TC isomer (reversed phase HPLC)
≤0.5% P(III) Impurities 145-155ppm (31P-NMR)
color
white to light yellow
solubility
acetonitrile: toluene (1:1): 0.1 M at 18 °C, clear
λ
conforms (UV/VIS Identity)
compatibility
configured for ABI
nucleoside profile
base: adenosine
base protecting group: benzoyl
2' protecting group: TC
5' protecting group: DMT
deprotection: fast
storage temp.
−20°C
SMILES string
COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](OC(=S)N3CCS(=O)(=O)CC3)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n4cnc5c(NC(=O)c6ccccc6)ncnc45)(c7ccccc7)c8ccc(OC)cc8
InChI
1S/C52H59N8O10PS2/c1-35(2)60(36(3)4)71(67-29-13-26-53)70-45-43(32-66-52(38-16-11-8-12-17-38,39-18-22-41(64-5)23-19-39)40-20-24-42(65-6)25-21-40)68-50(46(45)69-51(72)58-27-30-73(62,63)31-28-58)59-34-56-44-47(54-33-55-48(44)59)57-49(61)37-14-9-7-10-15-37/h7-12,14-25,33-36,43,45-46,50H,13,27-32H2,1-6H3,(H,54,55,57,61)/t43-,45-,46-,50-,71?/m1/s1
InChI key
CDNDGAZKHYLQRS-AEBGNYAMSA-N
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Legal Information
This product is manufactured and sold under a license from Agilent Technologies under under US Patent No. 8,202,983 and pending U.S. Patent App. Nos. 13/485,5925, 13/531,191, and 13/339,082 and corresponding foreign counterparts, including those issuing from PCT/US08/63342 and PCT/US09/057922 all assigned to Agilent Technologies. The purchase of this product conveys to the buyer the limited, non-exclusive, non-transferable right (without the right to resell, repackage, or further sublicense) under these patents to use the product to synthesize Oligonucleotides for buyer′s internal research use only, including commercial purposes. Except as otherwise provided herein, no other license is granted to the buyer weather expressly, by implication, by estoppel or otherwise. Buyer agrees and understands that it is not licensed to use this product to synthesize Oligonucleotides for sale, for diagnostic uses including use in clinical diagnostic settings where the use in conjunction with an individual′s sample generates data provided to an individual or the individual′s caregiver for a free reimbursement, neither can Oligonucleotides synthesized using this product be used for use clinical trials or for other therapeutic purposes. This product is sold pursuant to authorization from Agilent Technologies, Inc. and Agilent Technologies reserves all other rights under these patents.
For use with all sales where the purchaser is required to have its own direct license from Agilent, without limitation, Bulk Quantity Sales, and sales to Oligo Houses.
This product and it uses are covered by under US Patent No. 8,202,983 and pending U.S. Patent App. Nos. 13/485,5925, 13/531,191, and 13/339,082 and corresponding foreign counterparts, including those issuing from PCT/US08/63342 and PCT/US09/057922 all assigned to Agilent Technologies. This product is sold to purchaser pursuant to authorization by Agilent Technologies, Inc. without any rights conferred by seller, based on purchaser′s direct license and authorization to purchase from Agilent Technologies, Inc. No license is granted to the purchaser weather expressly, by implication, by estoppel or otherwise on account of this purchase. Purchase′s rights to use this product are governed solely and expressly by purchaser′s direct license agreement with Agilent.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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