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Merck
CN

A1987

AM6545

≥98% (HPLC)

Synonym(s):

5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C26H23Cl2N5O3S
CAS Number:
1245626-05-4
Molecular Weight:
556.46
NACRES:
NA.77
PubChem Substance ID:
329770727
UNSPSC Code:
12352200
MDL number:
MFCD19053178

Key Documents

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Product Name

AM6545, ≥98% (HPLC)

InChI key

XBHQLFVDGLPBCK-UHFFFAOYSA-N

SMILES string

Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(cc3)C#CCCC#N)C(=O)NN4CCS(=O)(=O)CC4

InChI

1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34)

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >25 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

AM6545 helps in decreasing the development of albuminuria, inflammation and expression of markers of fibrosis. It also helps in the down-regulation of nephrin and podocin. It has the ability to repress the ingestion of food and food-reinforced behaviour.
AM6545 is a peripheral CB1 cannabinoid receptor antagonist and appetite suppressant.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

AM6545 is a cannabinoid (CB1) receptor antagonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000487111
0000487110
0000487110
0000487111
0000355487

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Jin Zhang et al.
Molecular medicine reports, 19(3), 1491-1500 (2018-12-21)
Increasing evidence suggests that the dysregulation of microRNAs (miRNAs) has an important role in the progression of human cancer, including ESCC. However, the exact functions and mechanisms of miRNAs in ESCC remain largely unclear. The aim of the present study
Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy
Barutta F, et al.
British Journal of Pharmacology, 175(23), 4371-4385 (2018)
Christian Montellese et al.
eLife, 9 (2020-03-05)
Establishment of translational competence represents a decisive cytoplasmic step in the biogenesis of 40S ribosomal subunits. This involves final 18S rRNA processing and release of residual biogenesis factors, including the protein kinase RIOK1. To identify novel proteins promoting the final
The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior
Randall PA, et al.
Pharmacol. Biochem., 97(1), 179-184 (2010)
Songqing Tang et al.
Nature communications, 5, 4657-4657 (2014-08-15)
Host immune cells can detect and destruct invading pathogens via pattern-recognition receptors. Small Rap GTPases act as conserved molecular switches coupling extracellular signals to various cellular responses, but their roles as regulators in Toll-like receptor (TLR) signalling have not been
View All Related Papers

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