A1349
Monoclonal Anti-β-Amyloid (17-24) antibody produced in mouse
~1 mg/mL, clone 4G8, purified immunoglobulin, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
4G8, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 1:100-1:1000, immunoprecipitation (IP): 1:10-1:100, indirect ELISA: 1:103-1:105, western blot: 1:100-1:1000
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... APP(351)
Immunogen
synthetic peptide corresponding to amino acids 17-24 of the human β amyloid peptide with Glu substituted at position 11, conjugated to KLH.
Physical form
Solution in phosphate buffered saline.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
Regulatory Information
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Alina Hategan et al.
Nature structural & molecular biology, 24(4), 379-386 (2017-02-22)
Deposition of amyloid-β plaques is increased in the brains of HIV-infected individuals, and the HIV transactivator of transcription (Tat) protein affects amyloidogenesis through several indirect mechanisms. Here, we investigated direct interactions between Tat and amyloid-β peptide. Our in vitro studies
Stefania Zappettini et al.
Frontiers in pharmacology, 3, 146-146 (2012-08-07)
Using both in vitro (hippocampal synaptosomes in superfusion) and in vivo (microdialysis) approaches we investigated whether and to what extent β amyloid peptide 1-40 (Aβ 1-40) interferes with the cholinergic modulation of the release of glycine (GLY) in the rat
Chunyi Jiang et al.
Analytical and bioanalytical chemistry, 396(5), 1745-1754 (2010-02-06)
Aβ(1-42) is the proteolytic cleavage product of cleavage of the amyloid precursor protein by β- and γ-secretases. The aggregation of Aβ(1-42) plays a causative role in the development of Alzheimer's disease. To lock Aβ(1-42) in a homogenous state, we embedded
David A Bateman et al.
Biophysical journal, 96(10), 4260-4267 (2009-05-20)
Abeta42 has been found to associate rapidly to neuronal cells and is the primary constituent of senile plaques. In this study we monitored the aggregation of Abeta42 with living PC12 cells. Using photobleaching Förster resonance energy transfer, we observed one
Jason H Y Yeung et al.
Frontiers in neuroscience, 13, 1427-1427 (2020-02-06)
Alzheimer's disease (AD) is the leading type of dementia worldwide. Despite an increasing burden of disease due to a rapidly aging population, there is still a lack of complete understanding of the precise pathological mechanisms which drive its progression. Glutamate
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