A0851
Anti-Angiopoietin-2 antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-Ang-2
biological source
goat
Quality Level
recombinant
expressed in goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen ~66 kDa
species reactivity
human
technique(s)
ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL using human tissue
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ANGPT2(285)
General description
Angiopoietin 2 is an endothelial cell-specific protein and has a pivotal role in mature blood vessel formation, endothelial cell proliferation and embryogenic angiogenesis. Angiopoietin 2 produced by endothelial cells of interior tumor vessels, stimulates vessel regression and disassociation from surrounding tumor cells. Anti-angiopoietin-2 antibody can be used in western blotting. Goat anti-angiopoietin-2 antibody reacts specifically with recombinant human angiopoietin-2. The product may also show 25% (approx.) cross-reactivity for recombinant human angiopoietin-1.
Immunogen
purified recombinant human angiopoietin-2 expressed in mouse NSO cells.
Application
Anti-angiopoietin-2 antibody can be used in immunohistochemistry for detecting humanangiopoietin-2 using paraffin-embedded human tissue sections. It can also be used in ELISA.
Goat anti-angiopoietin-2 antibody is also suitable for use in western blot assays at 0.1-0.2 μg/mL
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (pH 7.4) with 5% trehalose
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Shigetomo Fukuhara et al.
Histology and histopathology, 25(3), 387-396 (2010-01-08)
Angiopoietin (Ang) 1 is a ligand for endothelium-specific receptor tyrosine kinase Tie-2. In adult vasculature, Ang1/Tie2 signaling is thought to regulate both maintenance of vascular quiescence and promotion of angiogenesis. However, it has been unknown how Tie2 signal regulates these
Jawun Choi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 117, 109091-109091 (2019-06-23)
Diosmetin is a natural flavonoid obtained from citrus fruits and some medicinal herbs. Previous studies have reported the anti-cancer activity of diosmetin in some types of tumors. However, it is still unclear whether diosmetin exerts anti-cancer effects, particularly anti-angiogenic effects
Z Zhou et al.
Cell death and differentiation, 22(3), 488-498 (2015-01-13)
Damage and loss of the postmitotic photoreceptors is a leading cause of blindness in many diseases of the eye. Although the mechanisms of photoreceptor death have been extensively studied, few studies have addressed mechanisms that help sustain these non-replicating neurons
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