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A0835

Sigma-Aldrich

N-Acetyl-Asp-Glu-Val-Asp-al

≥95%, powder

Synonym(s):

Ac-DEVD-CHO

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About This Item

Empirical Formula (Hill Notation):
C20H30N4O11
CAS Number:
169332-60-9
Molecular Weight:
502.47
MDL number:
MFCD00671412
UNSPSC Code:
12352209
PubChem Substance ID:
24890193
NACRES:
NA.32

biological source

synthetic

Quality Level

100

Assay

≥95%

form

powder

color

white

solubility

H2O: 1 mg/mL

storage temp.

−20°C

SMILES string

[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)

InChI key

UMBVAPCONCILTL-UHFFFAOYSA-N

Gene Information

human ... CASP1(834) , CASP3(836) , CASP7(840) , CASP8(841)

Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-al

General description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Application

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.
Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ4792
BCCC7362
BCCB3851
BCBV6599
BCBR4557V

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Journal of the American College of Cardiology, 38(7), 2063-2070 (2001-12-12)
The aim of this study was to investigate whether the caspase-3 inhibitor Ac-DEVD-CHO functionally improves stunned myocardium. Degradation of troponin I contributes to the pathogenesis of myocardial stunning, whereas the role of apoptosis is unknown. Caspase-3 is an essential apoptotic
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