R106
Ro 16-6491 hydrochloride
solid
Synonym(s):
N-(2-Aminoethyl)-4-chlorobenzamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C9H11ClN2O · HCl
CAS Number:
Molecular Weight:
235.11
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C9H11ClN2O.ClH/c10-8-3-1-7(2-4-8)9(13)12-6-5-11;/h1-4H,5-6,11H2,(H,12,13);1H
SMILES string
Cl.NCCNC(=O)c1ccc(Cl)cc1
InChI key
ARUMZUNJBHSOQQ-UHFFFAOYSA-N
form
solid
color
white
mp
216-217 °C
solubility
H2O: soluble
Gene Information
human ... MAOB(4129)
Biochem/physiol Actions
Selective, reversible, orally-active MAO-B inhibitor which is devoid of indirect sympathomimetic activity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Ro 16-6491: a new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP.
M Da Prada et al.
Advances in neurology, 45, 175-178 (1987-01-01)
Characterization of [3H]Ro 16-6491 binding to digitonin solubilized monoamine oxidase-B and purification of the enzyme from human platelets by affinity chromatography.
A M Cesura et al.
Biochemical pharmacology, 39(1), 216-220 (1990-01-01)
E L Mullan et al.
Journal of neural transmission. Supplementum, 41, 307-311 (1994-01-01)
Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro
A M Cesura et al.
Journal of neurochemistry, 48(1), 170-176 (1987-01-01)
The reversible inhibitor of monoamine oxidase type B (MAO-B) [3H]Ro 16-6491 binds specifically and with high affinity to a single population of binding sites in human frontal cortex crude mitochondria and platelet membranes. In both tissues binding equilibrium was reached
Interactions of the novel inhibitors of MAO-B Ro 19-6327 and Ro 16-6491 with the active site of the enzyme.
A M Cesura et al.
Pharmacological research communications, 20 Suppl 4, 51-61 (1988-12-01)
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