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Merck
CN

P8013

Pargyline hydrochloride

synthetic, 98% (TLC), MAO-B inhibitor, powder or crystals

Synonym(s):

N-Methyl-N-(2-propynyl)benzylamine hydrochloride, N-Methyl-N-propargylbenzylamine hydrochloride

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About This Item

Linear Formula:
C6H5CH2N(CH3)CH2C≡CH·HCl
CAS Number:
306-07-0
Molecular Weight:
195.69
NACRES:
NA.77
PubChem Substance ID:
24278153
UNSPSC Code:
12352200
EC Number:
206-175-1
MDL number:
MFCD00012492
Beilstein/REAXYS Number:
3699487

Key Documents

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Product Name

Pargyline hydrochloride,

InChI key

BCXCABRDBBWWGY-UHFFFAOYSA-N

InChI

1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H

SMILES string

Cl[H].CN(CC#C)Cc1ccccc1

biological source

synthetic

assay

98% (TLC)

form

powder or crystals

mp

160-163 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

Quality Level

200

Gene Information

human ... MAOA(4128), MAOB(4129)

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Application

Pargyline hydrochloride has been used:
  • as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training
  • to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats,
  • to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum

Biochem/physiol Actions

Pargyline hydrochloride acts as a histone demethylase inhibitor. It has antihypertensive action.
Selective MAO-B inhibitor.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBF3513V
STBB4464V
STBB4464
068K1468
087K1644

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Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors
Ifrim DC, et al.
Clinical and Vaccine Immunology : CVI, 21(4), 534-545 (2014)
Biochemical Pathway for the Formation of Abnormal Sclerotia of Sclerotinia sclerotiorum
Huang HC and Yeung JM
Plant Pathology, 11(1), 2-2 (2002)
An update on antidepressant toxicity: an evolution of unique toxicities to master
Liebelt EL
Clinical Pediatric Emergency Medicine, 9(1), 24-34 (2008)
Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation
Li S, et al.
Journal of Neurophysiology, 98(6), 3525-3537 (2007)
Erica P Cai et al.
Nature metabolism, 2(9), 934-945 (2020-07-29)
Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic beta cells. Pluripotent stem cells can now be differentiated into beta cells, thus raising the prospect of a cell replacement therapy for T1D. However, autoimmunity would rapidly destroy
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