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M9766

4-Methylumbelliferyl α-D-glucopyranoside

Name: 4-Methylumbelliferyl &#945;-<SC>D</SC>-glucopyranoside
Brand: SIGMA

α-glucosidase substrate, fluorogenic, ≥99% (TLC), powder

Synonym(s):

4-Methylumbelliferyl α-D-glucoside

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈O₈

CAS Number:

17833-43-1

Molecular Weight:

338.31

NACRES:

NA.32

PubChem Substance ID:

24897365

UNSPSC Code:

12352204

EC Number:

241-794-0

MDL number:

MFCD00067661

Beilstein/REAXYS Number:

1690776

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Properties

Product Name

4-Methylumbelliferyl α-D-glucopyranoside, α-glucosidase substrate

Quality Level

300

assay

≥99% (TLC)

form

powder

solubility

pyridine: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/m1/s1

InChI key

YUDPTGPSBJVHCN-JZYAIQKZSA-N

Description

Application

4-Methylumbelliferyl ǥ-D-glucopyranoside has been used to assay acid alpha-glucosidase (GAA) activity in tissue homogenates.

Biochem/physiol Actions

4-Methylumbelliferyl ǥ-D-glucopyranoside serves as a fluorogenic substrate for the ǥ-glucosidase enzyme. The product, 4-methylumbelliferyl, shows a peak at 440nm in the fluorescence spectra.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Articles

Probiotics and Human Health

Probiotics exhibit an inhibitory effect on pathogens, help prevent chronic intestinal inflammatory diseases or atopic syndromes, and support the immune system.

A new resorufin-based alpha-glucosidase assay for high-throughput screening.

Omid Motabar et al.

Analytical biochemistry, 390(1), 79-84 (2009-04-18)

Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have emerged as a new therapeutic

Intrapleural administration of AAV9 improves neural and cardiorespiratory function in Pompe disease.

Darin J Falk et al.

Molecular therapy : the journal of the American Society of Gene Therapy, 21(9), 1661-1667 (2013-06-05)

Pompe disease is a neuromuscular disease resulting from deficiency in acid α-glucosidase (GAA), results in cardiac, skeletal muscle, and central nervous system (CNS) pathology. Enzyme replacement therapy (ERT) has been shown to partially correct cardiac and skeletal muscle dysfunction. However

Copackaged AAV9 Vectors Promote Simultaneous Immune Tolerance and Phenotypic Correction of Pompe Disease.

Phillip A Doerfler et al.

Human gene therapy, 27(1), 43-59 (2015-11-26)

Pompe disease is a progressive neuromuscular disorder caused by lysosomal accumulation of glycogen from a deficiency in acid alpha-glucosidase (GAA). Replacement of the missing enzyme is available by repeated protein infusions; however, efficacy is limited by immune response and inability

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Global Trade Item Number

SKU	GTIN
M9766-10MG	04061834064565
M9766-25MG	04061835557783
M9766-100MG	04061834064558
M9766-250MG	04061835546190
M9766-1G	04061835557776