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96669

7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin

Name: 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin
Brand: SIGMA

suitable for fluorescence, BioReagent, ≥90% (HPCE)

Synonym(s):

1H-Pyrrole-2,5-dione, 1-(4-(7-(diethylamino)-4-methyl-2-oxo-2H-1-benzopyran-3-yl)phenyl)-, CPM

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₂N₂O₄

CAS Number:

76877-33-3

Molecular Weight:

402.44

NACRES:

NA.32

PubChem Substance ID:

57653774

UNSPSC Code:

12171500

MDL number:

MFCD00077334

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Properties

product line

BioReagent

Quality Level

100

assay

≥90% (HPCE)

form

solid

fluorescence

λ_ex 391 nm; λ_em 472 nm in methanol: 2-mercaptoethanol

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

CCN(CC)c1ccc2C(C)=C(C(=O)Oc2c1)c3ccc(cc3)N4C(=O)C=CC4=O

InChI

1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3

InChI key

YGIABALXNBVHBX-UHFFFAOYSA-N

Description

Application

Fluorescence probe for glutathione for intact cells; specific advantages: only thio derivative fluoresces, high quantum yield and good Stokes shift

Biochem/physiol Actions

Used to monitor release of thiols, quantitate thiol in microplate reactions, and to distinguish proliferating cancer cells by nucleolar protein staining.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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An essential role for the extracellular domain of the Na,K-ATPase beta-subunit in cation occlusion.

S Lutsenko et al.

Biochemistry, 32(26), 6737-6743 (1993-07-06)

The role of the Na,K-ATPase beta-subunit in stabilization of ion-binding sites has been investigated. Treatment of the purified renal Na,K-ATPase with 0.25 M DTT at 40 degrees C for 1 h resulted in 50% loss of Rb occlusion, which correlates

Somatosensory assessment and conditioned pain modulation in temporomandibular disorders pain patients.

Simple Futarmal Kothari et al.

Pain, 156(12), 2545-2555 (2015-08-27)

The pathophysiology and underlying pain mechanisms of temporomandibular disorders (TMD) are poorly understood. The aims were to assess somatosensory function at the temporomandibular joints (TMJs) and to examine whether conditioned pain modulation (CPM) differs between TMD pain patients (n =

A coupled fluorescent assay for histone methyltransferases.

Evys Collazo et al.

Analytical biochemistry, 342(1), 86-92 (2005-06-17)

Histone methyltransferases (HMTs) catalyze the S-adenosylmethionine (AdoMet)-dependent methylation of lysines and arginines in the nucleosomal core histones H3 and H4 and the linker histone H1b. Methylation of these residues regulates either transcriptional activation or silencing, depending on the residue modified

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Global Trade Item Number

SKU	GTIN
96669-10MG-F	04061833488676